The 3-hydroxy-3-methyl glutaryl CoA reductase (HMGR) is the key enzyme of mevalonate pathway in plants. A partial genomic DNA fragment encoding HMGR conserved domain (denoted as AbHMGR) is isolated from Aconitum balfourii Stapf. It comprises 871 bp encoding 290 amino acids. In silico analysis reveals that it had extensive similarities to other plant HMGR gene. Domain analysis of AbHMGR showed t...

INTRODUCTION Aconitine is a highly toxic diterpenoid alkaloid, produced by plants of the Aconitum genus, that is still used in Chinese herbal medicines. Aconitine poisoning remains common in China and other parts of Asia. CASE REPORT A 48-year-old man received a diagnosis of aconitine poisoning after ingesting herbal medicinal wine made with caowu, which is made from Aconitum kusnezoffii root...

BACKGROUND Benzoylmesaconine (BMA) is the main Aconitum alkaloid in Radix Aconiti Lateralis Preparata (Fuzi, aconite roots) with potent pharmacological activities, such as analgesia and anti-inflammation. The present study developed a simple and reliable method using BMA as a marker compound for the quality control of processed aconite roots and their products. METHODS After extraction, a hig...

Aconitum kusnezoffii used as an analgesic and anti-inflammatory. It is often not only in Mongolian medicine but also traditional Chinese medicine. However, there are few studies on its impact of inflammatory cytokines. This study explored the effects vitro human colon cancer (Caco-2) cells. Cytotoxicity was assessed by measuring expression IL-1β, IL-6, IL-8, TNF-α enzyme-linked immunosorbent as...

A study was carried out to elaborate the medicinal plant diversity at higher altitude of District Shangla, Khyber Pakhtunkhwa, Pakistan. The district is located between 33°-31' to 34°-08' North latitudes and 72°-33' to 73°-01' East longitude. Floristically the area comes under SinoJapanese region. The study revealed that there were 25 medicinal plant species belonging to 21 families. Among thes...

Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxida...

The title compound (delgradine), C(41)H(43)NO(12), is a hetisine-type C(20)-diterpenoid alkaloid, isolated from the roots of Aconitum carmichaeli Debx. In the crystal structure, the mol-ecule assumes an U-shaped conformation, the terminal benzene rings being approximately parallel and partially overlapped with each other. The mol-ecule contains eight alicyclic and heterocyclic rings. Cyclo-hexa...