PURPOSE The purpose of this study was to investigate the feasibility of poly lactic/glycolic acid (PLGA) as a drug delivery carrier of Rho kinase (ROCK) inhibitor for the treatment of corneal endothelial disease. METHOD ROCK inhibitor Y-27632 and PLGA were dissolved in water with or without gelatin (W1), and a double emulsion [(W1/O)/W2] was formed with dichloromethane (O) and polyvinyl alcoh...

introduction pyrite oxidation and acid mine drainage (amd) are the serious environmental problems associated with the mining activities in sulphide ores. the rate of pyrite oxidation is governed by the availability of oxygen (borden, 2003). therefore, the identifying oxygen supplying mechanism is one of the most important issues related to the environmental assessment of waste rock dumps (cathl...

Acid mine drainage (AMD) is a typical type of pollution originating from complex oxidation interactions that occur under ambient conditions in abandoned and active mines. AMD has high acidity contains concentration heavy metals metalloids, posing serious threat to ecological systems human health. Over the years, great progress been made prevention treatment AMD. Remediation approaches like chem...

Acid rock drainage (ARD) impacts species composition in mountain streams. The potential impact for riparian birds experiencing elevated metal uptake by consumption of benthic invertebrates is concerning but not well studied. We investigated the influence and rare earth element (REE) content on presence breeding an ARD-impacted watershed Colorado, USA, where tree swallows nest boxes had previous...

The high geostress and complex geological structure of underground powerhouse at Yebatan Hydropower Station frequently result in surrounding rock failure which delay construction schedule. Based on the microseismic monitoring technique, activity characteristics is analyzed under excavation disturbance intersection area shaft 2# drainage gallery. results show that events are concentrated rock, c...


 The overall aim of this undergraduate research was to quantify and identify trends within the bacterial environment at a non-acid mining drainage site in Lumberport, West Virginia, United States, due iron aluminum contamination. As environmental impact metal contaminants acid has been concern for decades, project is an excellent attempt assess whether filtration methods are local standar...

BACKGROUND Lysophosphatidic acid receptor 1 and Rho/ROCK signaling is implicated in bone cancer pain development. However, it remains unknown whether the two signaling pathways function together in P2X3 receptor-mediated bone cancer pain. RESULTS In this study, using a rat model of bone cancer, we examined the expression of P2X3 and lysophosphatidic acid receptor 1 in rat dorsal root ganglion...