A rapid and efficient one-pot, four-component protocol towards the synthesis of polyhydroquinoline derivatives has been developed. The condensation of aldehyde, dimedone, ethyl acetoacetate and ammonium acetate in presence of stannous chloride was carried out under solvent free condition to synthesize a variety of polyhydroquinoline derivatives in good to excellent yields. Stannous chloride was...

Reaction of thionyl chloride with 2-acetyl-1- benzenesulfonylpyrrole semicarbazone (6 c) gave 4 - (1- benzenesulfonyl-2 - pyrrolyl) - 1, 2, 3 -thiadiazole (lc). Selenium dioxide oxidation of 2-acetylpyrazine semicarbazone (10) in acetic acid afforded 4- (2-pyrazinyl) - 1, 2, 3- selenadiazole (4). Reaction of thionyl chloride with compound 10 gave 4- (2-pyrazinyl) - 1, 2, 3- thiadiazole (3)....

several cycline dependent kinase 2 (cdk2) inhibitors with different chemical structures have been introduced. the hinge region of cdk2 (residues 81–84) contains a set of hydrogen bond donor and acceptor sites some of which must be satisfied for potent inhibitor binding. the benzimidazolone skeleton may provide such interactions. accordingly, 3-sulfonamide substituted benzamido-benzimidazolones ...

This study verified the factors affecting antifungal efficacy of sanitizers against ochratoxin A-producing fungi. The fungi Penicillium nordicum, verrucosum, and Aspergillus westerdijkiae were exposed to three at concentrations: peracetic acid (0.3, 0.6, 1%), benzalkonium chloride 1.2, 2%), sodium hypochlorite (0.5, 0.75, 1%) exposure times (10, 15, 20 min), temperatures 25, 40 °C), with presen...

This research examined the effect of chemical factors (pH, sodium chloride, sugars (glucose and sucrose), preservatives (benzoic acid and sorbic acid)) and clove oil to decrease the growth of film yeasts (Saccharomyces cerevisiae J1, Candida krusei J2 and Candida krusei J3) on fermented bamboo shoots. All yeasts grew at pH 3.0-7.0 and did not grow greater than 7.5%(w/v) of sodium chloride conce...

THE EFFECT OF EXPOSING RABBIT RETICULOCYTE RIBOSOMES TO CONCENTRATED SOLUTIONS OF POTASSIUM CHLORIDE WAS EXAMINED BY: (a) dialysis against 0.5m-potassium chloride; (b) zone centrifugation through a sucrose gradient in 0.5m-potassium chloride; (c) differential centrifugation of a solution made 0.5m with respect to potassium chloride. The products of each treatment and their ability to support pr...

Enhanced airway smooth muscle (ASM) contraction is an important component in the pathophysiology of asthma. We have shown that ligand gated chloride channels modulate ASM contractile tone during the maintenance phase of an induced contraction, however the role of chloride flux in depolarization-induced contraction remains incompletely understood. To better understand the role of chloride flux u...

Modafinil [2-[(diphenylmethyl)sulfinyl]acetamide] is used clinically in the treatment of narcolepsy and sleeping disorders. The synthesis of modafinil, begins with the reaction of benzhydrol and thioglycolic acid in trifluoroacetic acid to afford benzhydrylsulfinyl acetic acid. The reaction of acid with thionyl chloride in benzene followed by treatment with ammonium hydroxide gave acetamide...

The presence of acetate in the bacterial medium leads to a reduction in the growth rate of cells and recombinant protein production. In this study, three compounds including propionic acid, lithium chloride and butyric acid were added to the medium which decreased acetate levels and enhanced recombinant protein production (alpha-synuclein). In fact, propionic acid and lithium chloride are both ...

Fe is an impurity in most leach liquors. Its coexistence with copper in leaching solution of chalcopyrite (CuFeS2) which is the most important mineral of copper creates major extraction problems. Hydrochloric acid dissolves both copper and iron during chloride leaching of this mineral. Separation of Fe from Cu is thus necessary to obtain pure copper. This paper presents a novel metho...