Major depressive disorder (MDD) has a lifetime prevalence of approximately 10% and is one the most common diseases worldwide. Although many pathogenetic mechanisms MDD have been proposed, molecular details unifying hypothesis pathogenesis remain to be defined. Here, we investigated whether tyrosine nitrosylation, which caused by reaction C-atom 3 phenol ring with peroxynitrate (ONOO−), plays ro...

The skin protects the human body by providing barrier function. Interleukin (IL)-33 is a tissue-derived cytokine, mainly expressed epithelial and endothelial cells, known to activate Th2 lymphocytes, mast ILC2, eosinophils. We aimed study role of IL-33 in Wild-type (WT), knockout (IL-33KO) mice were tape stripped, trans-epidermal water loss (TEWL) was monitored. Skin samples corrected, hematoxy...

In this work, the development of a new crystallization technique is reported, using nitrogen plasma (AC) to obtain nanostructured anatase and rutile from amorphous titanium oxide (TiO2). This methodology increases throughput and minimizes thermal effects. Nanostructured amorphous TiO2 was obtained by the sol-gel method and subsequently subjected to AC treatment, at a controlled pressure, applyi...

Oversupply of free fatty acids such as palmitic acid (PA) from the portal vein may cause liver insulin resistance. Production of reactive oxygen species plays a pivotal role in PA-induced insulin resistance in H4IIEC3 hepatocytes. Recently, we found that exosomes secreted from INS-1 cells that were transfected with neutral ceramidase (NCDase) plasmids had raised NCDase activity; these NCDase-en...