نتایج جستجو برای: acetylenic esters
تعداد نتایج: 28977 فیلتر نتایج به سال:
Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catecho...
a general, mild and efficient protocol has been developed for the synthesis of esters and thioesters. the process has been taking place using tetra n-butylammonium iodide (tbai) as a phase-transfer catalyst and in the presence of potassium carbonate (k2co3). a wide range of esters and thioesters was prepared in high yields and suitable times by the treatment of alcohols, phenols and thiols with...
conjugation of methotrexate (mtx) (mw 454) with different molecular weights of polyethylene glycol (peg) including methoxy-peg (mpeg) 750 d and 5000 d and diol-peg 35000 d led to compounds that are physicochemically highly different from the parent compound, mtx. in this study, an hplc system consisting of c8 column and uv detector (?=342 nm), using a mixture of 30:70 v/v phosphate-citrate buff...
A new and efficient preparation of pharmacologically and biologically important 2,5-disubstituted 6-azaindoles was achieved from cyclizations of aziridin-2-yl dipropargylic alcohols as adducts of two propargyl groups to ethyl 1-benzylaziridine-2-carboxylate. The sequential cyclizations include pyrrole formation and a novel base-catalyzed intramolecular acetylenic Schmidt reaction.
Synthesis of a 9-membered azaenediyne has been achieved for the first time via intramolecular N-alkylation; the importance of proximity of the reacting centres via cobalt carbonyl complexation of the acetylenic moiety and not the activation of propargylic carbon has been demonstrated.
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