Phormidium autumnale (P. autumnale) is a cyanobacteria with an unknown metabolic system, since only few studies have been reported. Among the produced metabolites, sterols profile important considering ability to this cyanobacterium in producing such compounds and their benefits for human health. In study, compressed fluid technologies were evaluated obtain phytosterol-rich extracts from P. inv...

Blueberries are rich in polyphenolic compounds and have shown improvement cognitive function several clinical trials. The molecular basis of the neuronal protection blueberries, however, is not fully understood. objective this research to understand biochemistry effects blueberries through their impacts on enzymes pathways involved Alzheimer’s disease (AD) other neurodegenerative diseases. We e...

Saponaria prostrata is a medicinal plant that contains various secondary metabolites such as phenolic acid, flavonoids, triterpenoids, and fatty acids are related to some biological activities. In this study, we evaluated the enzyme inhibitory, antimicrobial potentials of S. prostrata. The activity was measured using three Gram-positive, four Gram-negative bacteria species, fungi species. highe...

In the present study we describe the synthesis and biological assessment of new tacrine analogs in the course of inhibition of acetylcholinesterase. The obtained molecules were synthesized in a condensation reaction between activated 6-BOC-hydrazinopyridine-3-carboxylic acid and 8-aminoalkyl derivatives of 2,3-dihydro-1H-cyclopenta[b]quinoline. Activities of the newly synthesized compounds were...

The cholinergic system has been proposed to participate in the development of dependence on opioids. The present study examined effects of dermal pretreatment with methyl parathion (MP), an acetylcholinesterase inhibitor, on the development of physical dependence on morphine. Opioid dependence was induced by continuous intracerebroventricular (i.c.v.) infusion of morphine (26 nmol/μl/h) for 3 d...