Highlighting the work of outstanding young scientists at the chemical-and systems-biology interfaces Please take a look at the full table of contents to access the other papers in this issue. A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structu...

As a principal compound of cinnamon essential oil, cinnamaldehyde has been used as marker for the quality control and its oil. During HPLC analysis, reaction product was observed in methanol solution reference standard. This isolated identified to be dimethyl acetal based on spectroscopic analysis. Although dimethylacetalization MeOH recorded many literatures, this is first report about normal ...

To quantify the discolouration of temporary acetal resins in vivo, based on weeks follow-up and salivary pH three thirds tooth. find out if final CIELAB coordinates can be predicted from initial colour coordinates, pH, situation (in thirds) follow-up. Colour (L, C, h) were recorded by spectrophotometry 13 participants fitted with hybrid provisional complete dentures made resin. recordings day p...

2-Pyridylacetonitrile (1) couples with aromatic diazonium salts to yield arylhydrazones 2a-c, that were shown to exist in the syn-form 2 rather than the anti-form 4. Compounds 2a,c reacted with hydroxylamine in refluxing DMF to yield the interesting 1,2,3-triazolylpyridines 6. Attempts to cyclize 2 to give the corresponding fused pyrazolopyridines 9 failed. On the other hand, compound 1 condens...

A simple method for the diastereoselective synthesis of racemic 1,2-diol mediated by low-valence niobium generated in situ is described. A 1,4-dioxane-toluene solvent system was found to be essential to achieve higher selectivities and to prevent other reactions of pinacols, such as deoxygenation and acetal formation. Aromatic aldehydes and ketones were converted to the corresponding pinacols w...

We have built a new isonucleoside derivative on a 2,6-dioxobicyclo[3.2.0]heptane skeleton as a potential anti-HIV agent. To synthesize the target compound, an acetal-protected dihydroxyacetone was first converted to a 2,3-epoxy-tetrahydrofuran derivative. Introduction of an azide group, followed by the formation of an oxetane ring, gave a pseudosugar derivative with a 2,6-dioxobicyclo[3.2.0]hep...

Laminaribiose, which is the simplest -(1,3)-glucan, is one of the most powerful agents able to increase germination. Its chemical synthesis was revised in detail starting from peracylated donors and easily available glucofuranose protected by acetal groups in the presence of appropriated catalyst and/or promoter. We particularly focused our attention on the nature of the Lewis acid generally re...