Glycyrrhiza glabra (licorice), is used for therapeutic purposes since ages. Neuropathic pain a disease with complex pathophysiology, involving dysfunction in multiple ion channel receptors such as sodium, transient receptor potential channels, neurotransmitters, inflammatory mediators and reactive oxygen species. Network pharmacology newly emerging approach dealing understanding mechanism of ac...

Microencapsulation is one of the novel methods for retarding drug release from dosage forms and minimizing the adverse effects thereby increasing the patient compliance. Microspheres form homogeneous, monolithic particles which improve the treatment by providing localization of the drug at the site of action and by prolonging the drug release. The objective of the present study was to formulate...

the aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (ocmc) containing aceclofenac. a special technique was used while preparing an ocmc. stability of ocmc was determined in natural human saliva, and it was found that both ph and device are stable in human saliva. ocmc was evaluated by weight uniformity, thickness, hardness, friability, swelli...

A simple, selective, accurate high Performance Liquid Chromatographic (HPLC) method was developed and validated for the analysis of Paracetamol and Ibuprofen. Chromatographic separation achieved isocratically on a C18 column [Use Inertsil C18, 5μ , 150 mm x 4.6 mm] utilizing a mobile phase of acetonitrile/phosphate buffer (60:40, v/v, pH 7.0) at a flow rate of 0.8 ml/min with UV detection at 26...

The aim of present study was to prepare and characterized ethosomes of aceclofenac which may deliver the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. The formulations were prepared with varying the quantity of ethanol 10-50% (v/v), lecithin 1-4% (w/v), propylene glycol 5-20% (v/v) and evaluated for ...