to an Alu repetitive sequence 287 base pairs (bp) long has been described. The ACE inBackground – Inhibitors of angiotensin converting enzyme (ACE) cause a nonsertion/deletion polymorphism was found to be associated with serum levels of ACE and, in productive cough. The insertion/deletion polymorphism of ACE was used as a gensubjects who are homozygous for the D allele, the mean serum level of ...

Angiotensin-converting enzyme (ACE) gene polymorphism has been associated with increased incidence of stroke in some populations, although contradictory results have been reported. The aim of this study was to determine the allelic frequency and the genotypic distribution for ACE gene polymorphism in Turkish patients with ischemic stroke compared to appropriate healthy controls and to correlate...

AIM To evaluate the association between ACE gene polymorphism I/D and hypertension in Yogyakarta population. METHODS This study is a cross-sectional. Sample was taken by random sampling method from hypertensive, prehypertensve and normotensive subjects; from that were obtained 125 subjects, 97 subjects and 108 subjects, consecutively. ACE gene polymorphism I/D was examined by PCR. Genotype wa...

OBJECTIVE To find out the association of angiotensin converting enzyme (ACE) gene polymorphism with hypertension subtypes in a population from India. METHODS Consecutive subjects of either sex, aged > or =18 years attending in temporary field clinics arranged in various localities of Assam and Mizoram were interviewed to record information about socio-demographic characteristics, alcohol cons...

BACKGROUND The genetic influence on the myocardial performance index is uncertain, so the aim of the present study was to determine the effects of polymorphism of the angiotensin-converting enzyme (ACE) gene on the right ventricular myocardial performance index (RVMPI) after a first acute anterior myocardial infarction (MI). METHODS AND RESULTS The subjects were 116 patients with a first acut...

Background: Several studies investigated the association of ACE I/D polymorphism with the risk and severity of COVID-19 infection.  However, the information in each of the published studies is limited, and the results were inconsistent or even contradictory. Accordingly, this meta-analysis evaluated the association between the ACE I/D polymorphism and COVID-19 susceptibility and severity. Metho...

Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133) and FTO (rs9939609) genetic polymorphism in T2DM with dyslipi...

BACKGROUND The angiotensin-converting enzyme (ACE, CD143) gene plays a crucial role in the pathology of many cancers. Previous studies mostly focused on the gene polymorphism, but the other functions of ACE have rarely been reported. The purpose of this study was to investigate the expression of ACE and its biological function, as well as its prognostic value, in laryngeal cancer. MATERIAL AND ...

Renin angiotensin system (RAS) comprising Angiotensin converting enzyme (ACE), Angiotensin II (Ang II) and its receptor Angiotensin II receptor type I (AGTR1), plays a critical role in several diseases including cancer. A single nucleotide polymorphism (SNP) A1166C located in 3' untranslated region (UTR) of AGTR1 and an insertion/deletion (I/D) polymorphism present in intron 16 of ACE gene have...