Parallel Data processing has emerged to be one of the killer applications for Infrastructure-as-a-Service (IaaS) clouds. One of an IaaS cloud’s key feature is the provisioning of compute resources on demand. The computer resources available in the cloud are highly dynamic and possibly heterogeneous. Nephele is the first data processing framework to explicitly exploit the dynamic resource alloca...

Convenience, reliability, and effectiveness of automatic memory management have long been established in modern systems and programming languages such as Java. The timeliness requirements of real-time systems, however, impose specific demands on the operational parameters of the garbage collector. The memory requirements of real-time tasks must be accommodated with a predictable impact on the t...

Utility Accrual (UA) scheduling is a method of dynamic real-time scheduling that is designed to respond to overload conditions by producing a feasible schedule that heuristically maximizes a pre-defined metric of utility. Whereas utility accrual schedulers have traditionally focused on CPU overload, this dissertation explores memory overload conditions during which the aggregate memory demand e...

with Stage I and II disease there is excessive mortality per unit time as compared to the control population for at least 10 years after treatment. Thus, while the above definition is acceptable, the lag period required for the evaluation of potentially curative treatment is very long. In an attempt to determine the presence and degree of curative treatment in a shorter time, the relapse-free i...

Clinical trials are critical to improve AML treatment. It remains, however, unclear if clinical trial participation per se affects prognosis and to what extent the patients selected for trials differ from those of patients receiving intensive therapy off-trial.We conducted a population-based cohort study of newly diagnosed Danish AML patients treated with intensive chemotherapy between 2000-201...

Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression. However, recent findings of functional serotonergic pathways in bone cells and preliminary clinical evidence demonstrating detrimental effects of SSRIs on bone growth have raised questions regarding the...

This study is the first to investigate: (a) 'temporal performance fields,' whether the speed of information accrual differs for different locations at a fixed eccentricity, and (b) whether covert attention modulates temporal dynamics differentially at isoeccentric locations. Using the speed accuracy tradeoff (SAT) procedure, we derived conjoint measures of how isoeccentric locations and precuei...

White matter signal abnormality (WMSA) is often present in the MRIs of older persons with mobility impairment. We examined the relationship between impaired mobility and the progressive accrual of WMSA. Mobility was assessed with the Short Physical Performance Battery (SPPB) and quantitative measures of gait and balance. Fourteen subjects had baseline and follow-up MRI scans performed 20 months...

Methods The trial recruits men with locally advanced or metastatic prostate cancer starting standard long-term hormone therapy. There are 5 research arms and 1 control arm. The trial has a pilot stage assessing safety and feasibility, 3 intermediate “activity” stages (I-III) where the outcome measure is failure-free survival (FFS) and one final “efficacy” stage (IV) with overall survival as pri...

OBJECTIVE To study damage accrual and mortality in British patients with SLE under long-term follow-up for >10 years. METHODS We analysed the clinical records of 232 patients with SLE who had at least 10 years of consistent follow-up at University College London Hospital (UCLH). We noted their SLICC/ACR Damage Index (SDI) scores and category of damage at 1 year post-diagnosis of SLE and every...