Internet Electronic Conference of Molecular Design 2004, November 23 – December 6 Abstract Motivation. Chelatable methacrylates with phosphate groups, such as MDP, have been used as tooth-bonding agents in dentistry [1, 2]. MDP has shown acceptable pulp response and clinical performance. However, the effect of MDP on biological membranes remains unknown. Liposomes have been employed in model sy...

Modulation of myelopoiesis by three synthetic muramyl peptides was investigated in vivo. Two adjuvant-active compounds (N-acetylmuramyl dipeptide [MDP] and MDP-butyl-ester) elicited significant responses in DBA/2 mice characterized by a rise in the level of monocyte-macrophage colony-stimulating activity in serum, a proliferation of multipotential stem cells in the bone marrow, and an expansion...

6-O-(2-Tetradecylhexadecanoyl)-N-acetylmuramyl-L-alanyl-D-isoglutamine (B3O-MDP) and 6-O-(3-hydroxy-2-docosylhexacosanoyl)-MDP (BH48-MDP) were examined for immunopotentiating activity in stimulating the primary immune responses of guinea pigs to ovalbumin and for adverse reactions at the injection site and in the regional lymph nodes when administered in combination with several nonirritating v...

UNLABELLED Diabetic foot infection is the most common etiology of nontraumatic amputation of the lower extremities, and early diagnosis is of great importance in its management. The aim of this prospective study was to evaluate the strength of (99m)Tc-IgG scintigraphy in diagnosis of osteomyelitis of the diabetic foot and to compare (99m)Tc-IgG scintigraphy with (99m)Tc-methylene diphosphonate ...

introduction: the purpose of the present study was to evaluate the effect of prednisolone on the sensitivity of bone scanning to detect the simulated closed fracture in the rat tibia.  methods: a total number of forty eight adult, male nmri rats randomly assigned into two parts, one part for 4 and other for 8 weeks experiments. each part has been divided into four groups, one group not receivi...

BACKGROUND A prospective cohort study with university level participants was initiated to study the effect of Mediterranean diet on health. AIMS The objective of this study was to identify possible lifestyle and socioeconomic variables associated with the consumption of a Mediterranean dietary pattern (MDP). METHOD This analysis includes 1587 males and 2260 females. MDP was defined "a prior...

Muramyldipeptide (MDP), the minimum essential structure responsible for the immuno-adjuvant activity of peptidoglycan, is recognized by intracellular nuclear-binding oligomerization domain 2 (NOD2). Here, we obtained evidence that the treatment of human aortic endothelial cells (HAECs) with MDP up-regulated the gene expression of type I interferons in a dose- and time-dependent manner. MDP also...

N-Acetylmuramyi-L-alanyl-D-isoglutamine (muramyl dipeptide, MDP) 1 was shown (1) to be the minimal and essential s t ructure requi red for adjuvant activity o f bacterial cell wall peptidoglycans. Fur ther , MDP has been found to possess various biological activities, o ther than adjuvant activity, that are exer ted by bacterial cell wall peptidoglycans. Since MDP is such a potent immunomodula ...

The Multicast Dissemination Protocol (MDP) provides reliable multicast file and data delivery on top of the generic UDP/IP multicast transport. Early work on MDP was deployed across the global Internet Multicast Backbone (Mbone) as part of the publicly available Image Multicaster (IMM) application. This paper describes more recent work on MDP resulting in the MDP version 2 (MDPv2) toolkit. This...

The biosynthetic gene cluster for the enediyne antitumor antibiotic maduropeptin (MDP) from Actinomadura madurae ATCC 39144 was cloned and sequenced. Cloning of the mdp gene cluster was confirmed by heterologous complementation of enediyne polyketide synthase (PKS) mutants from the C-1027 producer Streptomyces globisporus and the neocarzinostatin producer Streptomyces carzinostaticus using the ...