Two protocols were performed to study meal fatty acid metabolism. In protocol 1, 14 patients scheduled for elective intra-abdominal surgery (11 undergoing bariatric surgery for severe obesity) consumed a meal containing [3H]triolein in the evening before surgery. This allowed us to measure adipose tissue lipid specific activity (SA) in mesenteric and omental, deep and superficial abdominal subc...

The insulin resistance syndrome X is related to excess intra-abdominal adipose tissue. With lipectomy of >50% of subcutaneous adipose tissue (SQAT) in nonhibernating, adult female Syrian hamsters on high-fat (HF; 50 calorie%) diet and measurements of oral glucose tolerance, oral [(14)C]oleic acid disposal, serum triglycerides, serum leptin, liver fat, perirenal (PR) adipose tissue cellularity, ...

OBJECTIVE To explore whether an imbalance between the visceral and subcutaneous fat depots and a corresponding dysregulation of the adipokine milieu is associated with excessive accumulation of fat in the liver and muscle and ultimately with insulin resistance and the metabolic syndrome. RESEARCH DESIGN AND METHODS We stratified our multi-ethnic cohort of 118 obese adolescents into tertiles b...

OBJECTIVE To test the hypothesis that intra-abdominal fat plays a primary role over general adiposity for metabolic abnormalities and atherosclerosis. RESEARCH DESIGN AND METHODS We cross-sectionally studied 849 Japanese men aged 50.3 +/- 8.5 years (range 20-78) with BMI 23.5 +/- 2.9 kg/m(2). Intimal-medial thickness (IMT) of the carotid artery was measured by ultrasound. General adiposity wa...

BACKGROUND Enlargement of adipocyte is associated with their dysfunction and alterations in metabolic functions. OBJECTIVES We evaluated the association of adipocyte size of subcutaneous and omental adipose tissue with body composition and cardiovascular risk factors in Asian Indians. METHODOLOGY Eighty (40 males and 40 females) non-diabetic adult subjects undergoing elective abdominal surg...

Utilizing a moderate rearing temperature regimen, two trials were conducted to determine the effect of dietary energy level on the amount of abdominal fat deposited when broilers are grown to equal body weight by varying growth time. The most abdominal fat (2.29% average of live weight for male and females) was produced by broilers offered a diet calculated to contain 3325 ME kcal/kg. The least...

BACKGROUND AND OBJECTIVE Different anatomical locations for measuring waist circumference are described in the literature but the best anatomical location for measuring waist circumference in older adults has yet to be established. Thus, an exploratory study was developed to examine which waist circumference best explains abdominal fat mass in older adults. METHODS Waist circumference was mea...

Objective—To determine if higher subcutaneous adipose tissue lipoprotein lipase activity (ATLPLA) is associated with greater triglyceride (TG) storage in subcutaneous adipose tissue (SAT), thereby reducing visceral adipose tissue (VAT) accumulation and metabolic dysfunction. Design and Method—Obese postmenopausal women (60±1 yrs; mean±SEM; N=101) had body composition by DXA and CT, fat aspirati...

BACKGROUND It was suggested that body fat distribution differs across ethnic groups, and this may be important when considering risk of disease. Previous studies have not adequately investigated differences in discrete regions of abdominal adiposity across ethnic groups. OBJECTIVE We compared the relation between abdominal adipose tissue and total body fat between persons living in Canada of ...

OBJECTIVE The purpose of this study was to determine the relationships between plasma adiponectin and leptin levels, total and central obesity, and glucose utilization across the adult age span. RESEARCH DESIGN AND METHODS We studied 148 women aged 18-81 years with a BMI range of 17.2-44.3 kg/m(2). Total percent body fat was determined by dual-energy X-ray absorptiometry and abdominal fat by ...