RECENT experiences with the treatment of saccular aneurysms of the aorta have shown that excision of an aneurysm in any portion of the aorta, with aortic suture, is feasible and that operative risk is not great.' Aneurysms of the distal abdominal aorta are in a more favorable position for surgical attack; however, such lesions are almost always caused by arteriosclerosis. The generalized distri...

1. Based on previous knowledge indicating that pan-phosphatidylinositol 3-kinease (PI3K) inhibitor treatment could suppress formation of experimental abdominal aortic aneurysms, what is the importance studying role PI3Kγ in AAAs?1A.PI3K significantly involved regular cellular functions and systemic inhibition PI3K has severe side effects.B.PI3Kγ mainly expressed infiltrated lymphocytes, which p...

Aortic aneurysms are relatively common maladies that may lead to the devastating consequence of aortic rupture. AAAs (abdominal aortic aneurysms) and TAAs (thoracic aortic aneurysms) are two common forms of aneurysmal diseases in humans that appear to have distinct pathologies and mechanisms. Despite this divergence, there are numerous and consistent demonstrations that overactivation of the RA...

Horseshoe kidney is a rare congenital anomaly that may cause various technical problems during conventional repairs of abdominal aortic aneurysms. We report the case of a 68-year-old woman with a horseshoe kidney, symptomatic abdominal aortic aneurysm and mild renal failure. The patient underwent endovascular repair using a bifurcated endoprosthesis. The postoperative was uneventful. We describ...

Objective The endovascular repair of aortic abdominal aneurysms exposes the patients and surgical team to ionizing radiation with risk of direct tissue damage and induction of gene mutation. This study aims to describe our standard of radiation exposure in endovascular aortic aneurysm repair and the factors that influence it. Methods Retrospective analysis of a prospective database of patient...

BACKGROUND Persons with abdominal aortic aneurysm are more likely to have a higher prevalence of risk factors for and clinical manifestations of cardiovascular disease. It is unknown whether these factors explain the high mortality rate associated with abdominal aortic aneurysm. OBJECTIVE To describe the risk for mortality, cardiovascular mortality, and cardiovascular morbidity in persons scr...

BACKGROUND Recently, thoracic aortic stent grafting has emerged as an alternative therapeutic modality for patients with thoracic aortic aneurysms and aortic dissections. However, its application has been limited to descending thoracic aortic aneurysms distal to the aortic arch. We report our initial clinical experience of endovascular branched stent graft repair for aortic arch aneurysms. ME...

Sarcoidosis is a systemic granulomatous disorder of unknown etiology, characterized by chronic noncaseating epitheloid granulomatous inflammation with tissue destruction [1,2]. Renal involvement affects 20% of patients with sarcoidosis [1,2] and can be found in patients with no other localizations of the disease [3]. A common cause of renal dysfunction is hypercalcaemia and hypercalciuria leadi...

OBJECTIVES To study the trend in incidence of aneurysms of the abdominal aorta in The Netherlands during the past two decades. SETTING The Dutch population from 1972 to 1992. DESIGN Analysis of all hospital admissions and deaths due to aneurysms of the abdominal aorta. OUTCOME MEASURES Age adjusted and age specific mortality and discharge rates. In-hospital mortality after surgery upon an...

The association of an axillary artery aneurysm and an abdominal aortic aneurysm is extremely rare. In this study, we describe this association in a 69 year-old-man. We measured this patient's metalloproteinases (MMPs) and Neutrophil Gelatinase - Associated Lipocalin (NGAL) levels over a three years period before the abdominal aortic aneurysm rupture. We speculate that high serium levels of MMPs...