نتایج جستجو برای: a1298c

تعداد نتایج: 565  

2013
Ti Zhang Jiao Lou Rong Zhong Jing Wu Li Zou Yu Sun Xuzai Lu Li Liu Xiaoping Miao Guanglian Xiong

BACKGROUND Neural Tube Defects (NTDs) are among the most prevalent and most severe congenital malformations worldwide. Polymorphisms in key genes involving the folate pathway have been reported to be associated with the risk of NTDs. However, the results from these published studies are conflicting. We surveyed the literature (1996-2011) and performed a comprehensive meta-analysis to provide em...

Journal: :American journal of epidemiology 2003
Astanand Jugessur Allen J Wilcox Rolv T Lie Jeffrey C Murray Jack A Taylor Arve Ulvik Christian A Drevon Hallvard A Vindenes Frank E Abyholm

Folic acid and the methylenetetrahydrofolate reductase (MTHFR) gene have both been implicated in the etiology of orofacial clefts. The authors selected 261 case-parent triads (173 cases with cleft lip with or without cleft palate (CL/P) and 88 cases with cleft palate only (CPO)) from a Norwegian population-based study of orofacial clefts (May 1996-1998). A case-parent triad design was used to e...

Journal: :Oncology reports 2008
Shin Sasaki Takashi Kobunai Joji Kitayama Hirokazu Nagawa

The prediction of the cellular direction of metabolic pathways toward either DNA synthesis or DNA methylation is crucial for determining the susceptibility of cancers to anti-metabolites such as fluorouracil (5-FU). We genotyped the methylenetetrahydrofolate reductase (MTHFR) gene in NCI-60 cancer cell lines, and identified the methylation status of 24 tumor suppressor genes using methylation-s...

Journal: :Carcinogenesis 2010
Mi-Sun Lee Li Su Eugene J Mark John C Wain David C Christiani

Measurement of carcinogen DNA adducts in blood has been used as a surrogate for the target lung tissue. We aimed to examine whether genetic polymorphisms in several metabolic pathway genes modify the relation between DNA adducts in target lung and blood. One hundred and thirty-five early-stage lung cancer patients from the Massachusetts General Hospital were studied. DNA adducts were measured b...

2009
Cyrus Cyril Padmalatha Rai N. Chandra P. M. Gopinath K. Satyamoorthy

BACKGROUND The 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and low folate levels are associated with inhibition of DNA methyltransferase and consequently DNA hypomethylation. The expanding spectrum of common conditions linked with MTHFR polymorphisms includes certain adverse birth outcome, pregnancy complications, cancers, adult cardiovascular diseases and psychiatric disorde...

2016
Cecilia Contreras-Cubas Beatríz E Sánchez-Hernández Humberto García-Ortiz Angélica Martínez-Hernández Francisco Barajas-Olmos Miguel Cid Elvia C Mendoza-Caamal Federico Centeno-Cruz Gabriela Ortiz-Cruz José Concepción Jiménez-López Emilio J Córdova Eva Gabriela Salas-Bautista Yolanda Saldaña-Alvarez Juan Carlos Fernández-López Osvaldo M Mutchinick Lorena Orozco

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folate deficiency has been related to several conditions, including neural tube defects (NTDs) and cardiovascular diseases. Hence, MTHFR genetic variants have been studied worldwide, particularly the C677T and A1298C. We genotyped the C677T and A1298C MTHFR polymorphisms in Mexican Amerindians (MAs), from the larg...

Journal: :Genetics and molecular research : GMR 2013
N Liu J Jiang Y J Song S G Zhao Z G Tong H S Song H Wu J Y Zhu Y H Gu Y Sun W Hua J P Qi

Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation. As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may regulate ...

2015
Mohamed N. Saad Mai S. Mabrouk Ayman M. Eldeib Olfat G. Shaker Pablo Garcia de Frutos

Rheumatoid arthritis (RA) is an autoimmune disease which has a significant socio-economic impact. The aim of the current study was to investigate eight candidate RA susceptibility loci to identify the associated variants in Egyptian population. Eight single nucleotide polymorphisms (SNPs) (MTHFR-C677T and A1298C, TGFβ1 T869C, TNFB A252G, and VDR-ApaI, BsmI, FokI, and TaqI) were tested by genoty...

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