The non-coding transcriptome of the hyperthermophilic archaeon Pyrococcus abyssi is investigated using the RNA-seq technology. A dedicated computational pipeline analyzes RNA-seq reads and prior genome annotation to identify small RNAs, untranslated regions of mRNAs, and cis-encoded antisense transcripts. Unlike other archaea, such as Sulfolobus and Halobacteriales, P. abyssi produces few leade...

Aristotle holds that individual substances are ontologically independent from nonsubstances and universal substances but that non-substances and universal substances are ontologically dependent on substances. ! ere is then an asymmetry between individual substances and other kinds of beings with respect to ontological dependence. Under what could plausibly be called the standard interpretation,...

game where agents learn prediction models regarding potential coalition partners and thus, can respond in an agile manner to situations that are occurring in the grid, by means of negotiating and formulating a priori solutions , with respect to the estimated behaviour of the system. To sum up, we are providing a novel framework for managing the grid efficiently by envisioning a game layer on to...

Computerized navigation surgery has evolved to facilitate minimally invasive procedures, the gold standard of surgery today. While flapless implant surgery may be clinically beneficial, it has generally been perceived as a blind procedure limited to straightforward cases that do not pose a risk of cortical plate perforation. The objective of this report is to describe a protocol for flapless im...

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status, and a regulator of energy balance at both the cellular and whole body levels. Although ubiquitously expressed, its function is best understood in skeletal muscle. AMPK contains sites that reversibly bind AMP or ATP, with an increase in cellular AMP:ATP ratio (signalling a fall in cellular energy status) switching on ...

It is still an open question in parallel discrete event simulation what conditions influence the performance of parallel simulation paradigms. We have developed a simulation environment based on asynchronous cellular automata that facilitates basic research into the concepts of discrete event simulation and parallel discrete event simulation, such as the Time Warp paradigm. We address the trans...

Various feature descriptions are being employed in logic program ming languages and constrained based grammar formalisms The com mon notational primitive of these descriptions are functional attributes called features The descriptions considered in this paper are the possi bly quanti ed rst order formulae obtained from a signature of binary and unary predicates called features and sorts respect...

Du point de vtte sociologique, un nouveau palier a 6t6 franchi dans l'intdgration de l 'Europe, alors qu'ailleurs on assiste ~l la r6surgence des nutionalismts. A lu conscience de plus eu plus nette tie la dimensicm mondialt des grands ddfis posds 'a l 'humanit6 s 'oppose une relent6 de plus en plus aigue de reconstruire les identit6s nationales. Or, comme I'a si bitn (lit Hag~gt, "les langues ...

This study was conducted to investigate the feasibility of using 3D virtual intravascular endoscopy (VIE) as a novel approach for characterization of calcified coronary plaques with the aim of differentiating superficial from deep calcified plaques, thus improving assessment of coronary stenosis.A total of 61 patients with suspected coronary artery disease were included in the study. Minimal lu...