Intramolecular general base catalysis by the imidazolyl group was found in the hydrolyses of endo-5-[4;(5')-imidazolyl]-bicyclo[2.2.1]hept-endo-2-yl trans-cinnamate and endo-5-[4'(5')-imidazolyl]bicyclo[2.2.2]oct-endo-2-yl trans-cinnamate in which the imidazolyl and trans-cinnamoyl groups are bound in close proximity to each other by rigid bicyclic rings. The rate constants for the intramolecul...

http://bmj.com/cgi/content/full/330/7487/347 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/330/7487/347/DC1 "References w1 w29" References http://bmj.com/cgi/content/full/330/7487/347#BIBL This article cites 20 articles, 8 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/330/7487/347 You can re...

An improved synthesis of bicyclo[2.2.1]hept-5-ene-2,3-dione by Swern oxidation of bicyclo[2.2.1]hept-5-ene-2,3-diol, and an unexpected ring-opening reaction by the Swern oxidation of pyrazine-fused congeners are described.

In the context of the search for gasoline surrogates for kinetic modeling purpose, this paper describes a new model for the low-temperature auto-ignition of n-heptane/iso-octane/hexene/toluene blends for the different linear isomers of hexene. The model simulates satisfactory experimental results obtained in a rapid compression machine for temperatures ranging from 650 to 850 K in the case of b...

The synthetic host cucurbit[7]uril (CB[7]) binds aromatic guests or metal complexes with ultrahigh affinity compared with that typically displayed in protein-ligand binding. Due to its small size, CB[7] serves as an ideal receptor-ligand system for developing computational methods for molecular recognition. Here, we apply the recently developed variational implicit-solvent model (VISM), numeric...

The 1:1 co-crystallization of 1,4-di-aza-bicyclo-[2.2.2]octane (DABCO) with 4-nitro-benzoic acid in ethanol-water (3/1) gave the salt dihydrate C6H13N2 (+)·C7H4NO4 (-)·2H2O, (1), whereas from methanol, the salt C6H14N2 (2+)·2C7H4NO4 (-), (2), was isolated. In (1), the cation and anion are linked by a strong N-H⋯O hydrogen bond, and the carboxyl-ate anion is close to planar [dihedral angle betwe...

松下 亨 The present investigation was performed in order to clarify the mechanism of ataxic behavior following the administration of 2-(3-dimethylaminopropyl)-1,3,3a,4,9,9a-hexa hydro-4,9-o-benzeno-2H-benz[f]isoindole dimethiodide (MI-65-S) to mammals. For several years, many bis-quaternary ammonium salts containing a bicyclo(2.2.2) octane ring in their large cationic head have been synthesized in...