Thermal analysis of acrylonitrile/acrylic acid P(AN/AA) copolymer films containing 5%, 10% and 20% acrylic acid dendrigrafted with citric acid (CA) is examined using differential scanning calorimetry (DSC) with various heating rates, thermogravimetry (TGA) and derivative thermogravimetric analysis (DTG). Also, the effect of carboxylic acid on thermal stabilization of the P(AN/AA) copolymers, wh...

In the structure of the title compound, C(8)H(12)NO(+)·C(7)H(5)O(6)S(-)·H(2)O, isolated from the reaction of 2-(4-amino-phen-yl)ethanol with 5-sulfosalicylic acid, the cations form head-to-tail hydrogen-bonded chains through C(1) (1)(9) anilinium N(+)-H⋯O(hydrox-yl) inter-actions while the anions also form parallel but C(1) (1)(8)-linked chains through carboxylic acid O-H⋯O(sulfonate) inter-act...

Superoxide activates nucleotide-sensitive mitochondrial proton transport through the uncoupling proteins UCP1, UCP2, and UCP3 (Echtay, K. S., et al. (2002) Nature 415, 1482-1486). Two possible mechanisms were proposed: direct activation of the UCP proton transport mechanism by superoxide or its products and a cycle of hydroperoxyl radical entry coupled to UCP-catalyzed superoxide anion export. ...

8-Hydroxy-2-[2-(3-hydroxy-4-methoxyphenyl)ethenyl]-7-quinoline carboxylic acid and 8-hydroxy-2-[2-(3-methoxy-4-hydroxyphenyl)ethenyl]-7-quinoline carboxylic acid inhibit the processing and strand transfer reactions catalyzed by HIV-1 integrase with an IC50 of 2 microM. Some of their spectral properties are briefly reported. Their fluorescence is so weak that it is of no use in an experimental d...

barium salts of dibenzylidene cystines 8a-c were obtained from the reaction of lcystine with benzaldehyde or its derivatives in the presence of barium hydroxide. their reduction with zinc and hydrochloric acid in methanol yielded the narylmethylcysteines ?9a-c?. these can, in turn, be converted by esterification into the methyl esters ?10 a-c. ?reaction of n, n'-carbonyl diimidazole (im co...

with urease. A third minor metabolite was present in urine collected after intraperitoneal administration but remains unidentified. The quantitative distribution of pterin-dcarboxylic acid and urea in the 0-24 h urine samples is shown in Table 1. Fukushima & Nixon (1980) reported the degradation of [2-14C]pterin-6-carboxylic acid to 14C02 by the gut microorganisms of the rat. It is possible tha...

In the structure of the 1:1 proton-transfer compound of isopropyl-amine with 4,5-dichloro-phthalic acid, C(3)H(10)N(+)·C(8)H(3)Cl(2)O(4) (-), the three cation H-atom donors associate with three separate carboxyl O-atom anion acceptors, giving conjoint cyclic R(4) (4)(12), R(4) (4)(16) hydrogen-bonding cation-anion inter-actions in a one-dimensional ribbon structure. In the anions, the carboxyl ...

The N-methyl-D-aspartate (NMDA) receptor family regulates various central nervous system functions, such as synaptic plasticity. However, hypo- or hyperactivation of NMDA receptors is critically involved in many neurological and psychiatric conditions, such as pain, stroke, epilepsy, neurodegeneration, schizophrenia, and depression. Consequently, subtype-selective positive and negative modulato...