background almost one-third of the world's population is infected with mycobacterium tuberculosis, but only 10% of them develop tuberculosis. tnf-α/il-10 balance has key roles in controlling latent/activation stages of tuberculosis. objectives the objective of this study was to determine an association between polymorphic variants of the tnf-α and il-10 genes and tuberculosis. patients and meth...

patients and methods eighty-three patients with diagnosis of nafld, and 93 healthy subjects were included in the study. tetra arms-pcr was designed to detect single nucleotide polymorphisms. results a significant difference was found between nafld and control group regarding the rs266729 polymorphism (χ2 = 7.35, p = 0.025). the rs266729 polymorphism increased the risk of nafld in codominant (cc...

type 2 diabetes mellitus (t2d) is the most common metabolic disease demonstrating itself by hyper- glycemia, due to impaired insulin secretion or action. recently, whole-genome association studies have revealed the role of several new genes responsible for t2d. one of the most studied genes is slc30a8 (zn-t8) which is exclusively expressed in pancreatic ?-cells and participates in insulin stora...

Oxidative stress is an important risk factor for cardiovascular diseases. Although a variety of genetic factors are assumed to contribute to the regulation of oxidative stress, evidence in human populations is insufficient. In this study, we therefore evaluated the effects of six functional single-nucleotide polymorphisms (SNPs) on the oxidative stress under a cross-sectional study design. Part...

glaucoma is a major cause of blindness worldwide. a single nucleotide polymorphism of the mthfr gene (c677t) has been associated with susceptibility to this disease, although this is controversial in the last decade. in this study, the possible association between the mthfr c677t polymorphism and the risk of developing primary open angle (poag) and pseudoexfoliation glaucoma (pexg) was investig...

Background: Due to the lack of information about the role of 4G/5G polymorphism of PAI-1 Gene in susceptibility to thyroid tumors, this study was performed to evaluate the potential effects of this polymorphism on clinicopathologic features of thyroid tumors in Iranian Azeri Turkish patients. Methods:In this case-control study, 90 patients with thyroid tumors ...

Background and Aims: This research aimed to study a possible link between endometriosis and polymorphism of the progesterone receptor gene. Materials and Methods: The control group consisted of 86 women without endometriosis and the case group comprised 86 patients with a diagnosis of endometriosis by laparoscopy. Genotypes for Alu insertion polymorphisms (A1/A1, A1/A2 and A2/A2) were descri...