نتایج جستجو برای: 68ga psma

تعداد نتایج: 2775  

2017
Helena Virtanen Johanna M U Silvola Anu Autio Xiang-Guo Li Heidi Liljenbäck Sanna Hellberg Riikka Siitonen Mia Ståhle Meeri Käkelä Anu J Airaksinen Kerttuli Helariutta Tuula Tolvanen Tibor Z Veres Antti Saraste Juhani Knuuti Sirpa Jalkanen Anne Roivainen

Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1). We compared 68Ga-DOTA- and 18F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation. Methods. Firstly, we examined 68Ga-DOTA-Siglec-9 and 18F-FDR-Siglec-9 in rats with skin/muscle inflammation. We then studied 18F-FDR-Siglec-...

2015
Hai-long Wang Shao-shan Wang Wen-hui Song Yi Pan Hai-peng Yu Tong-guo Si Yong Liu Xiao-nan Cui Zhi Guo

BACKGROUND Prostate-specific membrane antigen (PSMA) has been found in tumor neovasculature endothelial cells (NECs) of non-prostate cancers and may become the most promising target for anti-tumor therapy. To study the value of PSMA as a potential new target for lung cancer treatment, PSMA expression in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) tissues and its relatio...

Journal: :International journal of oncology 2012
Kai-Yuan Cao Lin Xu Ding-Mei Zhang Xiao-Ming Zhang Tian Zhang Xia He Zhu Wang Fa-Shen Feng Shao-Peng Qiu Guan-Xin Shen

PSM-E is a newly discovered alternatively spliced variant of prostate-specific membrane antigen (PSMA). In the current study, its role on the proliferation, invasiveness and migration in prostate cancer cell lines was analyzed. PSM-E and PSMA (as a comparison) eukaryotic expression vectors pcDNA3.0/PSM-E and pcDNA3.0/PSMA were constructed, validat...

2016
Isabel Rauscher Tobias Maurer Wolfgang P. Fendler Wieland H. Sommer Markus Schwaiger Matthias Eiber

Recently, positron emission tomography (PET) imaging using PSMA-ligands has gained high attention as a promising new radiotracer in patients with prostate cancer (PC). Several studies promise accurate staging of primary prostate cancer and restaging after biochemical recurrence with (68)Ga-PSMA ligand Positron emission tomography/computed tomography (PET/CT). However, prospective trials and cli...

Journal: :Molecular imaging 2011
Maarten Brom Lieke Joosten Peter Laverman Wim J G Oyen Martin Béhé Martin Gotthardt Otto C Boerman

In comparison to somatostatin receptor scintigraphy, gastrin receptor scintigraphy using 111In-DTPA-minigastrin (MG0) showed added value in diagnosing neuroendocrine tumors. We investigated whether the 68Ga-labeled gastrin analogue DOTA-MG0 is suited for positron emission tomography (PET), which could improve image quality. Targeting of cholecystokinin-2 (CCK2)/gastrin receptor-positive tumor c...

Journal: :The Prostate 2017
Ismaheel O Lawal Alfred O Ankrah Neo P Mokgoro Mariza Vorster Alex Maes Mike M Sathekge

BACKGROUND Emerging data from published studies are demonstrating the superiority of Ga-68 PSMA PET/CT imaging in prostate cancer. However, the low yield of the Ge-68/Ga-68 from which Gallium-68 is obtained and fewer installed PET/CT systems compared to the SPECT imaging systems may limit its availability. We, therefore, evaluated in a head-to-head comparison, the diagnostic sensitivity of Ga-6...

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