Blockade of hERG K(+) channels in the heart is an unintentional side effect of many drugs and can induce cardiac arrhythmia and sudden death. It has become common practice in the past few years to screen compounds for hERG channel activity early during the drug discovery process. Understanding the molecular basis of drug binding to hERG is crucial for the rational design of medications devoid o...

Citation: Firrao G, Torelli E, Polano C, Ferrante P, Ferrini F, Martini M, Marcelletti S, Scortichini M and Ermacora P (2018) Genomic Structural Variations Affecting Virulence During Clonal Expansion of Pseudomonas syringae pv. actinidiae Biovar 3 in Europe. Front. Microbiol. 9:656. doi: 10.3389/fmicb.2018.00656 Genomic Structural Variations Affecting Virulence During Clonal Expansion of Pseudo...

Citation: Staley C, Breuillin-Sessoms F, Wang P, Kaiser T, Venterea RT and Sadowsky MJ (2018) Urea Amendment Decreases Microbial Diversity and Selects for Specific Nitrifying Strains in Eight Contrasting Agricultural Soils. Front. Microbiol. 9:634. doi: 10.3389/fmicb.2018.00634 Urea Amendment Decreases Microbial Diversity and Selects for Specific Nitrifying Strains in Eight Contrasting Agricult...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 207 No. 5 643–656 www.jcb.org/cgi/doi/10.1083/jcb.201404128 JCB 643 Correspondence to Tina Izard: izard{at}scripps.edu Abbreviations used in the paper: CC, correlation coefficient; FA, focal adhesion; MEF, mouse embryonic fibroblast; PC, phosphatidylcholine; PIP2, phosphatidylinositol 4,5-bisphosphate; VBS, vinculin binding site; VH, vi...

We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.

1General Thoracic Surgery, Hoshigaoka Medical Center, Osaka 873-8511, Japan. 2First Department of Surgery, Hamamatsu Medical University School of Medicine, Shizuoka 431-3192, Japan. 3Department of Respiratory Surgery Saitama Cardiovascular and Respiratory Center, Saitama 360-0105, Japan. 4Department of Thoracic and Cardiovascular Surgery, Nara Medical University, Nara 634-8522, Japan. 5Departme...

E. Mikuli, A. Migdał-Mikuli, I. Natkaniec', and J. Mayer Faculty of Chemistry of the Jagiellonian University, ulica Ingardena 3, 30-060 Krakow, Poland a Frank Laboratory of Neutron Physics, JINR, 141980 Dubna, Russia b H. Niewodniczanski Institute of Nuclear Physics, ulica Radzikowskiego 152, 31-342 Krakow, Poland Reprint requests to Dr. E. M.; Fax: (+4812) 634 05 15, E-mail: [email protected]...

During the initial six week period of deployment and jungle training in Belize, a 634 man strong infantry battalion group sustained twenty-three machete hand injuries. Eighteen were treated at battalion level, while five required hospital treatment. The management of these injuries is considered.

Beatriz C. Abreu, PhD, OTR, FAOTA, is Independent Consultant and Clinical Professor, School of Health Professions, University of Texas Medical Branch, PO Box 2547, Galveston, TX 77553; [email protected] Abreu, B. C. (2011). Accentuate the positive: Reflections on empathic interpersonal interactions (Eleanor Clarke Slagle Lecture). American Journal of Occupational Therapy, 65, 623–634. doi: 10.50...