Photochemistry provides a wide range of alternative reagents that hold potential for use in bimolecular functionalisation proteins. Here, we report the synthesis and characterisation metal ion binding chelates derivatised with disubstituted tetrazoles photoradiochemical labelling monoclonal antibodies (mAbs). The photophysical properties featuring extended aromatic systems auxochromic substitue...

We have studied trehalose uptake in Salmonella typhimurium and the possible involvement of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) in this process. Two transport systems could recognize and transport trehalose, the mannose PTS and the galactose permease. Uptake of trehalose via the latter system required that it be expressed constitutively (due to a galR or galC mut...

BACKGROUND Gold nanoshells are excellent agents for photothermal ablation cancer therapy and are currently under clinical trial for solid tumors. Previous studies showed that passive delivery of gold nanoshells through intravenous administration resulted in limited tumor accumulation, which represents a major challenge for this therapy. In this report, the impact of direct intratumoral administ...