Oxidation of uracil (U) and thymine (5-Me-U) are believed to play a role in genetic instability because of the changes these oxidations cause in the ionization constants (pKa values), which in turn affects the base pairing and hence coding. However, interpretation of the experimental evidence for the changes of pKa with substitution at U has been complicated by the presence of two sites (N1 and...

Silica-bonded N-propyldiethylenetriamine (7) is employed as a recyclable heterogeneous solid base catalyst for the synthesis of 2-amino-3,5-dicarbonitrile-6-thiopyridines through pseudo four-component condensation reaction between aromatic aldehydes, malononitrile, and 2-amino-thiophenol in refluxing ethanol. Silica-bonded N-propyldiethylenetriamine showed much the same efficiency when used in ...

amino acid dehydrogenases (l-amino acid: oxidoreductase deaminating ec 1.4.1.x) are members of the wider superfamily of oxidoreductases that catalyze the reversible oxidative deamination of an amino acid to its keto acid and ammonia with the concomitant reduction of either nad+, nadp+ or fad. these enzymes have been received much attention as biocatalysts for use in biosensors or diagnostic kit...