A novel and facile route to functionalized mono/bicyclic 2,3-dihydro-4-pyridones has been developed via formal [5C + 1N] annulation of readily available alpha-alkenoyl ketene-(S,S)-acetals with various aliphatic primary amines.

The complex-forming ability of 2-methyl-3-hydroxypyran-4-one (1a), 2-ethyl-3-hydroxypyran-4-one (1b), 1,2-dimethyl-3-hydroxypyridin-4-one (4a) and 1-ethyl-2-methyl-3-hydroxypyridin-4-one (4b) with nickel(Ni(II)) were characterized by infrared, ultraviolet, proton nuclear magnetic resonance spectroscopy and melting point. The mole-ratio of nickel:ligands was analyzed by atomic-absorption-spectro...

Myosin 5c (Myo5c) is a low duty ratio, non-processive motor unable to move continuously along actin filaments though it is believed to participate in secretory vesicle trafficking in vertebrate cells. Here, we measured the ATPase kinetics of Myo5c dimers and tested the possibility that the coupling of two Myo5c molecules enables processive movement. Steady-state ATPase activity and ADP dissocia...

The reaction of 1-adamantyl isothiocyanate 4 with the various cyclic secondary amines yielded the corresponding N-(1-adamantyl)carbothioamides 5a-e, 6, 7, 8a-c and 9. Similarly, the reaction of 4 with piperazine and trans-2,5-dimethylpiperazine in 2:1 molar ratio yielded the corresponding N,N'-bis(1-adamantyl)piperazine-1,4-dicarbothioamides 10a and 10b, respectively. The reaction of N-(1-adama...

The text Rom 9:5 is referred to as crux interpretum in exegetical studies and considered one of the most difficult passages Letter Romans. In history exegesis, various ways interpreting eulogy 9:5c have been proposed. contemporary debate primarily whether be applied Christ or God. It has acknowledged that interpretation remains a question solve. Several points view speak for fact ὁ &#803...

the complex-forming ability of 2-methyl-3-hydroxypyran-4-one ( 1a ), 2-ethyl-3-hydroxypyran-4-one ( 1b ), 1,2-dimethyl-3-hydroxypyridin-4-one ( 4a ) and 1-ethyl-2-methyl-3-hydroxypyridin-4-one ( 4b ) with nickel(ni(ii)) were characterized by infrared, ultraviolet, proton nuclear magnetic resonance spectroscopy and melting point. the mole-ratio of nickel:ligands was analyzed by atomic-absorption...

Medical laboratories often produce clinically unexpected results that require timely clinical evaluation because they herald an imminent life-threatening condition or major clinical deterioration. Laboratories therefore need to proac-tively identify and report such results sooner than would routinely occur, and have policies and procedures that minimize the possibility of patient harm due to de...