Aberrant cytoplasmic aggregation of FUS, which is caused by mutations primarily in the C-terminal nuclear localisation signal, is associated with 3% of cases of familial amyotrophic lateral sclerosis (ALS). FUS aggregates are also pathognomonic for 10% of all frontotemporal lobar degeneration (FTLD) cases; however, these cases are not associated with mutations in the gene encoding FUS. This sug...

Our group has challenged the concept that S. epidermidis (SE) is only a beneficial commensal microbe by showing when skin colonization of SE increases, it promotes inflammation through production protease EcpA. Analysis genome revealed encodes 4 genes homologous to α-type phenol soluble modulin (PSM) toxic peptide made aureus (SA), thus suggesting another mechanism which can harm skin. Principl...

CHEK2 is a protein kinase that is involved in cell-cycle checkpoint control after DNA damage. Germline mutations in CHEK2 gene have been associated with increase in breast cancer risk. The aim of this study is to identify the CHEK2 gene germline mutations among high-risk breast cancer patients and its contribution to the multiethnic population in Malaysia. We screened the entire coding region o...

booklet for Nonlinear Physics: Theory and Experiment. III Gallipoli (Lecce, Italy) 24 June – 3 July 2004 Information received within June 15, 2004 —————————————————————————————Mark J. Ablowitz Department of Applied Mathematics, University of Colorado UCB 526, Boulder 80309 CO Chazy-Darboux-Halphen Systems At the turn of the last century Painlevé and his school obtained a class of ordinary diffe...

PURPOSE There is growing evidence implicating that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in the development and progression of cancers. However, the effect of NGAL in colorectal carcinoma (CRC) has not been clearly elucidated. In this study, we investigated the role of NGAL in the tumorigenesis and progression of CRC and evaluated the clinical value of NGAL expression. ...

Desmosine (D) and isodesmosine (I), the intramolecular crosslinking amino acids that occur in chains of elastin, have now been found in free form in human urine. Until now, these amino acids (M(r) = 526) were found to occur in urine only as higher molecular weight (M (r) = 1,000-1,500) peptides. Thus, the previously used analytical methods required, as the first step, acid hydrolysis of the uri...

Elevated plasma fibrinogen levels and tumor progression in patients with gastric cancer (GC) have been largely reported. However, distinct fibrinogen chains and domains have different effects on coagulation, inflammation, and angiogenesis. The aim of this study was to characterize fibrinogen β chain (FGB) in GC tissues. Retrospectively we analyzed the data of matched pairs of normal (N) and mal...