PURPOSE Aberrant arachidonic acid (AA) metabolism, especially through the cyclooxygenase (Cox) and 5-lipoxygenase (5-Lox) pathways, has been suggested to play an important role in the development of esophageal adenocarcinoma (EAC). The purpose of this study was to investigate the expression of 5-Lox in EAC of a rat model and in human samples as well as the chemopreventive effects of zileuton (a...

An important trend in current toxicology is the replacement, reduction, and refinement of the use of experimental animals (the 3R principle). We propose a model in which in vivo genotoxicity and short-term carcinogenicity assays are integrated with F344 gpt delta transgenic rats. Using this model, the genotoxicity of chemicals can be identified in target organs using a shuttle vector lambda EG1...

The mode of action for the reproductive toxicity of some triazole antifungals has been characterized as an increase in serum testosterone and hepatic response, and reduced insemination and fertility indices. In order to refine our mechanistic understanding of these potential modes of action, gene expression profiling was conducted on liver and testis from male Wistar Han IGS rats exposed to myc...

Bu çalışma, Bu-Ter tere (Lepidium sativum L.) tohumlarına ön uygulama olarak ağır metal kurşunun farklı konsantrasyonları ve vermikompost uygulamasının çimlenme fide gelişim parametrelerine etkisi belirlenmesi amacıyla tesadüf parselleri deneme desenine göre üç tekrarlamalı yürütülmüştür. Çalışma Siirt Üniversitesi Bahçe Bitkileri Bölümü Laboratuvarında gerçekleştirilmiştir. Denemede kullanılan...

The social environment plays a critical role in smoking initiation as well as relapse. We previously reported that rats acquired nicotine self-administration with an olfactogustatory cue only when another rat consuming the same cue was present during self-administration. Because carbon disulfide (CS2) mediates social learning of food preference in rodents, we hypothesized that socially acquired...

Carbon monoxide (CO) in expired gas has been shown to be elevated with asthma; however, its function is not known, and there is some potential that it may serve a bronchoprotective role to decrease airway hyperresponsiveness (AHR). Thus the ability of CO to reverse methacholine (MCh)-induced bronchoconstriction was evaluated in C57BL/6 (C57) and A/J mice with and without airway inflammation pro...

Introduction: Observations of terrestrial levels of highly volatile elements in lunar apatite, including H [1-3], suggested that some lunar melts were at least “damp” if not “wet” at some point in their histories. On the other hand, the very high δCl values in lunar rocks and apatites (up to ~+30‰ [4]) have been taken to mean that their parent magmas were essentially anhydrous, because such lar...

As part of a quality assurance (QA) study for sensor systems, an enclosureapproach is applied to assess the accuracy of non-dispersive infrared (NDIR)-based CO₂sensors. To examine the performance of the sensor system, an enclosure chambercontaining six sensor units of the two model types (B-530 and H-500) was equilibratedwith calibrated CO₂ standards at varying concentration levels. Initially, ...