The efficacies of tigecycline and ceftazidime against fatal pneumonia in rats caused by an extended-spectrum β-lactamase (ESBL)-positive Klebsiella pneumoniae strain or its wild-type (WT) progenitor were compared. Ceftazidime at 12.5 or 50 mg/kg of body weight twice daily (b.i.d.) was effective (50% or 100% rat survival) in pneumonia caused by the WT isolate but unsuccessful (100% rat mortality...

Methods Sixteen patients affected by SoJIA (12 F, 4 M) were switched to Anakinra. Patients received Anakinra (in association with MTX) at the dose of 100 mg daily (> 50 kg) or at the dose of 1–2 mg/kg daily (< 50 kg). All patients failed previous DMARDS and TNF inhibitors. Paediatric patients were evaluated according to the ACR30 paediatric criteria. Adults were evaluated according to EULAR cri...

The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...

Background: Cylophosphamide is used alone or in combination with other drugs for treatment of neoplastic diseases. Hemorrhagic cystitis is a major potential toxicity and dose limiting side effect of cyclophosphamide. The aim of this study was to evaluate the effects of lycopene compared with some antioxidants for the prevention of cyclophosphamide induced hemorrhagic cystitis in rats. Methods: ...

The leaves of the plants Daniellia oliveri (Fabaceae) and Ficus sycomorus (Moraceae) used in diarrhea treatment in Hausa ethnomedicine of Northern Nigeria were investigated. The study was carried out on perfused isolated rabbit jejunum and castor oil-induced diarrhea in mice. The n-butanol extracts: NBD and NBF (0.16-3.2 mg/ml) caused a dose-dependent relaxation of isolated rabbit jejunum. The ...

The effect of clindamycin (CLI) combined with autovaquone (ATO) was examined in a murine model of acute toxoplasmosis. Swiss Webster mice intraperitoneally infected with 10(2) or 10(4) tachyzoites of the RH strain of Toxoplasma gondii were perorally treated with either drug alone (for ATO, 5, 25, 50, or 100 mg/kg of body weight/day; for CLI, 25, 50, or 400 mg/kg/day) or both combined (for ATO p...

Durian seed flour can be used for the manufacture of food products such as sticks and steamed sponges. Sticks sponge cake are foods that many people like from children to adults. is rich in minerals including magnesium, potassium, calcium phosphorus. This study aims determine content phosphorus durian using Atomic Absorption Spectrophotometer (SSA) UV-Vis Spectrophotometry. The results showed m...

OBJECTIVE The purpose of this study was to compare the in vivo anti-tumor efficacy of a mucoadhesive, lipid-based, oral paclitaxel formulation (DHP107) with traditional, intraperitoneal (IP) paclitaxel using an orthotopic mouse model of chemotherapy-sensitive SKOV3ip1 ovarian cancer. METHODS To determine the optimal therapeutic dose of oral paclitaxel, DHP107 was administered per os to female...

introduction: high environmental temperature during summer months which leading to heat stress, is of great concern in all types of poultry production. feed consumption, growth rate, hatchability, mortality, and other important traits governing the prosperity of the industry are adversely affected by severe heat stress. literature suggests that the advantages of dietary l-carnitine and ascorbic...