نتایج جستجو برای: 5 fluorophenyl 1

تعداد نتایج: 3371655  

Journal: :Acta Crystallographica Section E Structure Reports Online 2011

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

Journal: :Acta crystallographica. Section C, Structural chemistry 2014
Seranthimata Samshuddin Jerry P Jasinski James A Golen Badiadka Narayana Hemmige S Yathirajan Christopher Glidewell

Two different heterocycles, a pyrazole and an oxadiazine, are formed by the reactions of a common precursor, (2RS,3SR)-2,3-dibromo-1,3-bis(4-fluorophenyl)propan-1-one, with different simple hydrazines. In 3,5-bis(4-fluorophenyl)-1-phenyl-1H-pyrazole, C(21)H(14)F(2)N(2), (I), formed using phenylhydrazine, there is some aromatic-type delocalization in the pyrazole ring, and the molecules are link...

1997
SHIGERU OKUYAMA SHIGEYUKI CHAKI RYOKO YOSHIKAWA YOSHIKO SUZUKI SHIN-ICHI OGAWA YASUKO IMAGAWA NAOYA KAWASHIMA YOKO IKEDA TOSHIHITO KUMAGAI ATSURO NAKAZATO MASASHI NAGAMINE KAZUYUKI TOMISAWA

(R)-(1)-2-Amino-4-(4-fluorophenyl)-5-[1-[4-(4-fluorophenyl)-4oxobutyl]pyrrolidin-3-yl]thiazole (NRA0045), a novel thiazole derivative, has high affinities for the human cloned dopamine D4.2, D4.4 and D4.7 receptors, with Ki values of 2.54, 0.55 and 0.54 nM, respectively. NRA0045 is approximately 91-fold more potent at the dopamine D4.2 receptor, compared with human cloned dopamine D2L receptor....

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