PURPOSE To determine whether inhibition of TGFβ signaling prior to irradiation sensitizes human and murine cancer cells in vitro and in vivo. EXPERIMENTAL DESIGN TGFβ-mediated growth and Smad phosphorylation of MCF7, Hs578T, MDA-MB-231, and T47D human breast cancer cell lines were examined and correlated with clonogenic survival following graded radiation doses with and without pretreatment w...

Purpose: To determine whether inhibition of TGFb signaling prior to irradiation sensitizes human and murine cancer cells in vitro and in vivo. Experimental Design: TGFb-mediated growth and Smad phosphorylation of MCF7, Hs578T, MDAMB-231, and T47D human breast cancer cell lines were examined and correlated with clonogenic survival following graded radiation doses with and without pretreatment wi...

background: the present study was performed to investigate the effects of trace elements particularity se, zn and cu on tumor genesis in breast cancer. methods: the inhibitory effect of se, zn and cu, on telomerase activity was analyzed in human breast tumor tissues and breast cancer (t47d) cells. tissue specimens from 24 women with benign breast disease and 32 women with breast cancer specimen...

Metaplastic Breast Carcinoma (MBC) is one among the rare types of breast carcinoma. MBC was recognised as a separate entity by World Health Organisation (WHO) in 2020. According to WHO, metaplastic carcinoma classified into six based on histology which includes: low grade adenosquamous carcinoma; fibromatosis like squamous cell spindle with heterologous mesenchymal differentiation; and mixed ca...

PURPOSE The universal organic solvent dimethyl sulfoxide (DMSO) can be used as a differentiation inducer of many cancer cells and has been widely used as a solvent in laboratories. However, its effects on breast cancer cells are not well understood. The aim of this study is to investigate the effect and associated mechanisms of DMSO on mouse breast cancer. METHODS We applied DMSO to observe t...

Cancer vaccination may be our best and most benign option for preventing or treating metastatic cancer. However, breakthroughs are hampered by immune suppression in the tumor microenvironment. In this study, we analyzed whether cyclic diguanylate (c-di-GMP), a ligand for stimulator of interferon genes (STING), could overcome immune suppression and improve vaccination against metastatic breast c...

Metastasis currently remains the predominant cause of breast carcinoma treatment failure. The effective targeting of metastasis-related-pathways in cancer holds promise for a new generation of therapeutics. In this study, we developed an novel Asp-UA conjugate, which was composed of classical "old drug" aspirin and low toxicity natural product ursolic acid for targeting breast cancer metastasis...

Purpose: To determine whether inhibition of TGFb signaling prior to irradiation sensitizes human and murine cancer cells in vitro and in vivo. Experimental Design: TGFb-mediated growth and Smad phosphorylation of MCF7, Hs578T, MDAMB-231, and T47D human breast cancer cell lines were examined and correlated with clonogenic survival following graded radiation doses with and without pretreatment wi...

BACKGROUND Metastasis is the major cause of cancer related death and targeting the process of metastasis has been proposed as a strategy to combat cancer. Therefore, to develop candidate drugs that target the process of metastasis is very important. In the preliminary studies, we found that schisandrin B (Sch B), a naturally-occurring dibenzocyclooctadiene lignan with very low toxicity, could s...

BACKGROUND Breast cancer is the leading cause of cancer death among women worldwide and metastasis is the major cause of treatment failure. Thus, new treatment options for breast cancer, especially, drugs which could prevent metastasis, are pressingly needed. METHODS In the present study, we designed and synthesized a novel cinnamide derivative, (E)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropa...