Using the liver 9000 x g supernatant fraction of uninduced rats and monospecific antibodies against microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P450 reductase and two inducible forms of cytochrome P-450, PB-P-450 (major cytochrome P-450 component of the liver microsomes of phenobarbital-treated rats) and MC-P-448 (major cytochrome P-450 component of the liver micro...

Rat liver microsomes contain three spectrally distinguishable forms of cytochrome P-450. Each form is identified qualitatively and quantitatively by visible spectral changes that occur when the cytochromes P-450 combine with various ligands, such as cyanide. In addition to cytochrome P-450, rat liver microsomes also contain cytochrome b6, which may be removed from the microsomes by digestion wi...

The spin state of cytochrome P-450 ferric iron in uiuo and in oitro was examined in freshly prepared liver microsomes from rabbit, guinea pig, hamster, mouse, and rat by low temperature electron paramagnetic resonance CEPR) spectroscopy and compared with room temperature difference spectral changes. Simple liquids of known relatively “pure” type I, reverse type I, and type II tcyclohexane, buta...

We estimated genetic parameters for various phases of body and testicular growth until 550 days of age in Nelore cattle, using Bayesian inference, including correlation values and error estimates. Weight and scrotal records of 54,182 Nelore animals originating from 18 farms participating in the Brazilian Nelore Breeding Program (PMGRN) were included. The following traits were measured: we...

Studies involving the metabolism of chemical carcinogens were important in the discovery and initial characterization of the cytochrome P-450 enzyme system. The Millers and their associates identified NADPH-dependent microsomal enzymes involved in the biotransformation of azo dyes (1, 2). These reactions, reduction and mixed-function oxidation, were also found to be important in the processing ...

INTRODUCTION .......................................................................................................................................................440 CLASSIFICATION SCHEMES ................................................................................................................................440 MOLECULAR CLASS A CARBAPENEMASES ............................................