A tetrazole ring is often used in drug discovery as a replacement for the carboxylic acid group. Previous work indicates that compounds containing a tetrazole moiety show asymmetric permeability in Caco-2 cells characteristic of an efflux transporter substrate. The aim of this study is to determine which transporters are responsible for polarization of transport of tetrazole-containing compound...

Biobased monomers derived from castor oil as well as from limonene suitable for thiol–ene copolymerization were synthesized. Di‐10‐undecenylether 2 was obtained via GaBr3‐catalyzed reduction of 10‐undecenyl 10‐undecenoate 1. Diene ether 2 and (R)‐limonene 5 were reacted in two steps using radical thiol–ene addition reactions to dithiol ether 4 and dithiol 7, respectively. Diene ether 2 and dith...

Thiol esters, such as aeetyl coenzyme A, the principal biological carrier of activated acetyl groups, have generally been supposed to be “energy-rich” compounds; i.e. to have a free energy of hydrolysis at pH 7.0 in the range of -7000 to -14,000 calories per mole. The reported numerical values for the free energy of thiol ester hydrolysis have varied over a wide range (for recent estimates see ...

The aim of this study was to improve the mucoadhesive potential of xyloglucan polymer by the covalent attachment of cysteine as thiol moiety. The parent polymer xyloglucan was chemically modified by introducing sulphydryl bearing compound L-cysteine HCl. Different batches of xyloglucan-cysteine conjugates were prepared at varying reaction pH (2-6) and evaluated for optimum thiol incorporation, ...

Nitrogen rich compounds are suitable as ingredients in low smoke propellant charges. Several high-N energetic materials are presented which are based on tetrazoles. Tetrazoles are an unique class of compounds, since they combine a high nitrogen content and a high heat of formation with good thermal and kinetic stabilities due to their aromatic ring system. The reaction of 5azidotetrazole with h...

A readily accessible iridium(iii) phenyl-tetrazole complex ([Ir(ptrz)2(tBu-bpy)]+, 2; Hptrz = 2-methyl-5-phenyl-tetrazole; tBu-bpy = 4,4'-di-tert-butyl-2,2'-bipyridine) is shown to be a versatile catalyst for a new photocatalytic Michael reaction. Under light irradiation in the presence of 2, a dithiane 2-carboxylic acid, obtained by simple hydrolysis of a commercially available ethyl ester, ge...

A series of new N-substituted derivatives of 5-benzyl-1, 3, 4-oxadiazole-2yl-2"-sulfanyl acetamide (6a-n) were synthesized in three phases. The first phase involved the sequentially converting phenyl acetic acid into ester, hydrazide and finally cyclized in the presence of CS2 to afford 5-benzyl-1, 3, 4-oxadiazole-2-thiol. In the second phase N-substituted-2-bromoacetamides were prepared by rea...

In the title compound, C22H18N8 H2O, the dihedral angle between the tetrazole rings is 69.58 (1) while the terminal phenyl ring makes dihedral angles of 26.98 (8) and 39.75 (8) with the other benzene rings. The rings of the biphenyl unit subtend a dihedral angle of 55.23 (8) . In the crystal, the solvent water molecule is linked to the main molecule via an N—H O hydrogen bond. In addition, C—H ...