Dipeptidyl peptidase 4 (DPP-4; also known as CD26), a transmembrane receptor expressed on T cells, has costimulatory function in activating cells. In mouse model, down-regulation of CD26 prevented graft-versus-host disease (GVHD) but preserved graft-versus-tumor effects. Whether inhibition DPP-4 with sitagliptin may prevent acute GVHD after allogeneic stem-cell transplantation is not known.

the androgen insensitivity syndrome is a heterogeneous disorder with a wide spectrum of phenotypic abnormalities, ranging from complete female to ambiguous forms that more closely resemble males. the primary abnormality is a defective androgen receptor protein due to a mutation of the androgen receptor gene. this prevents normal androgen action and thus leads to impaired virilization. a point m...

the present study describes the changes in expression of hydroxy- carboxylic acid receptor 2 (hca2 receptor) in femoral epiphysis and metaphysis of rats with glucocorticoid-induced osteoporosis (gio). 16 growing male sprauge dawley rats were randomly divided into two equal groups consisting of normal control and rats that were rendered osteoporotic by receiving 0.1 mg/kg/day dexamethasone throu...