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Para-aminohippuric acid (PAH) accumulates against a concentration gradient in the ciliary body and independently in the iris of the rhesus monkey eye. This accumulation is inhibited by incubation of 0 degrees C and shows saturation kinetics in both tissues. Cyanide, ouabain, dinitrophenol, iodopyracet, and probenecid effectively depress PAH uptake in both tissues, but anaerobic incubation condi...

The effect of overproduction of interleukin (IL) 5 on the allergic cutaneous response was investigated in transgenic mice overexpressing IL-5. Five repeated topical applications of 2, 4-dinitrofluorobenzene (DNFB) to the ears of mice resulted in allergic dermatitis on the ears as well as significant elevation in dinitrophenol-specific IgE antibody and total IgE in the serum in both wild-type an...

In the preceding paper (1) it was pointed out that the administration of sodium salicylate to man induces a number of changes suggestive of thyrotoxicosis. There is an elevated basal metabolic rate (BMR), negative nitrogen balance, a fall in the cholesterol level of the hypothyroid subject, and an accelerated fractional disappearance rate of labeled thyroxine from the circulation. Paradoxically...

In 1955 Hollunger (1) showed that with isolated mitochondria, guanidine, methylguanidine, and asym-dimethylguanidine inhibited the adenosine diphosphate-stimulated oxidation of those substrates with diphosphopyridine nucleotide-linked dehydrogenases, whereas succinate oxidation was far less affected. When dinitrophenol was used to stimulate respiration, no marked inhibition was noted. Hollunger...

Considerable attention has been given in the past to the action of parathyroid hormone in promoting calcium mobilization and phosphate diuresis (1). In an effort to gain some insight into the mechanism of action of parathyroid hormone at the molecular level, studies on its biochemical action at the subcellular level have been pursued in this laboratory. It has been shown that parathyroid hormon...

Certain organs and glands of animals (whether susceptible to scurvy or not) have been shown by biological tests and reduction with the indophenol indicator to contain ascorbic acid (vitamin C) in higher concentration than most of the other tissues. Thus, the anterior lobe of the pituitary, corpus luteum, thymus, suprarenals, and, to a lesser extent the liver, are rich in the vitamin. The ascorb...

Growth of the excised axis of Phaseolus vulgaris L. (var. White Marrowfat) begins after a 7-hour incubation in buffer or water at 26 degrees . Growth, as measured by axis elongation or fresh weight increase, is linear for at least 8 hours with a resultant fresh weight increase of approximately 65%. Cell elongation begins 4 or 5 hours prior to cell division and 5 or 6 hours prior to radicle prot...