A series of polysubstituted 1,4-dihydropyridines (4a-i) were designed and developed using Ph-B(OH)2 catalyst. Further, compounds confirmed by various spectroscopic techniques. After that all studied for molecular docking against the human peroxidase enzyme (1PRX). Results revealed many exhibited low binding score. To get a reference from study, synthesized molecules evaluated in vitro antioxida...

Nifedipine is a dihydropyridine calcium-channel blocker (CCB) introduced approximately 30 years ago for the prophylaxis of angina symptoms, and then later utilized as an anti-hypertensive agent. In the 1990s, several meta-analyses and a case-control study were published which raised concern regarding increased mortality and increased risk for myocardial infarction with short-acting nifedipine. ...

An ytterbium catalyzed formal [3+3] cycloaddition of cyclic enamines and ?,?-unsaturated ketones is reported. The reaction proceeds with a ‘head to tail’ regioselectivity through conjugate addition the enamine moiety followed by an amine-carbonyl condensation. In use chiral provided high degree stereoselectivity, driven possible balance between steric ?-stacking effects. resulting bicyclic 1,4-...

In the title compound, C(21)H(25)NO(4), the dihydropyridine ring adopts a flattened boat conformation. The N atom and the sp(3) C atom deviate in the same direction from the mean plane of the other four C atoms, by 0.269 (6) and 0.111 (6) Å, respectively. This mean plane is inclined to the 4-methoxy-phenyl ring by 87.3 (5)°. The cyclohexenone ring has a sofa conformation with the C atom bearing...

In the title compound, C(21)H(27)NO(5), the dihydropyridine ring adopts a boat conformation. The ethoxy-phenyl ring is oriented approximately perpendicular to the planar part of the dihydropyridine ring, making a dihedral angle of 89.45 (6)°. An intra-molecular C-H⋯O hydrogen bond generates an S(6) ring motif. In the crystal structure, neighbouring mol-ecules are linked into chains along the a ...

significance as calcium-channel modulators in the treatment of cardiovascular diseases, such as hypertension, cardiac arrythmias or angina.1 In recent years, interest has also been focused on aza-analogs of dihydropyridines, such as dihydropyrimidines, which show a very similar pharmacological profile to that of dihydropyridine calcium channel modulators.2 In a continuation of these studies, ri...

The effects of pharmacological agents on the T-type Ca2+ current were studied in dissociated spermatogenic cells from the mouse. Ca2+ currents were elicited by depolarization in 10 mM Ca2+ and recorded in the whole-cell configuration of the patch clamp technique. The T-type current was inhibited by the following compounds: PN200-110 (IC50 = 4 x 10(-8) M) > nifedipine (IC50 = 4 x 10(-7) M) > pim...