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the recent article by Di Geronimo et al was highly interesting1. The Authors have clearly demonstrated the efficacy of alpha-lipoic acid in the treatment of carpal tunnel syndrome. The findings of Di Geronimo et al are highly important as they further highlight the rapidly expanding role of alpha-lipoic acid in the management of other neurological conditions besides carpal tunnel syndrome. For ...
5-Aminopyrazole-4-carbonitrile and ethyl 5-aminopyrazole-4-carboxylate, as potential trifunctional building blocks are introduced in a facile, chemo- and regioselective multicomponent assembly of imidazo[1,2-b]pyrazoles via the Groebke-Blackburn-Bienaymé reaction (GBB reaction). Besides the synthetic elaboration of a green-compatible isocyanide-based access in three-component mode, we describe ...
Why does the physical 4-dimensional space have a 3 + 1 signature rather than a 4 + 0 or a 2 + 2 for its metric? We give a simple explanation based largely on a group-theoretic argument a la Wigner. Applied to flat spaces of higher dimensions the same approach indicates that metrics with more than one time dimension are physically unacceptable because the corresponding irreducible unitary repres...
Current study is aimed to compare fluride release in conventional glass ionomer, light-cured glass ionomer and compomers. Standard samples from the aforementioned materials were prepared and measured by selective fluride ion electrode in intervals of 24hours, 1,2,3 and 4 weeks in neutral PH of 7 and acidic PH of 4.5. The obtained data represented that fluride ion release decreased in time but...
there exists a symplectic irreducible 4-manifold X with π1(X) = G and (c 2 1(X), χh(X)) = (c, χ). The characteristic numbers are given in terms of χh = 1/4(e+σ) and c 2 1 = 2e+3σ, where e is the Euler characteristic of the manifold X and σ its signature. To describe conditions under which smooth 4-manifolds are unique has been a theme in 4-manifold theory for quite some time. Besides its role i...
The design and synthesis of Lamellarin D conjugates with a nuclear localization signal peptide and a poly(ethylene glycol)-based dendrimer are described. Conjugates 1-4 were obtained in 8-84% overall yields from the corresponding protected Lamellarin D. Conjugates 1 and 4 are 1.4- to 3.3-fold more cytotoxic than the parent compound against three human tumor cell lines (MDA-MB-231 breast, A-549 ...
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