A bioassay of 1,5-naphthalenediamine for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. 1,5-Naphthalenediamine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The high and low dietary concentrations utilized in the chronic bioassay were, respectively, 0.1 and 0.05 percent for rats and 0.2 ...

The effect of plasma on degradation of human growth hormonereleasing hormone (GRH) was examined in vitro and in vivo using high performance liquid chromatography (HPLC), radioimmunoassay (RIA), and bioassay. When GRH(1-44)-NH2 was incubated with human plasma, the t1/2 of total GRH immunoreactivity was 63 min (RIA). However, HPLC revealed a more rapid disappearance (t1/2, 17 min) ofGRH(144)-NH2 ...

Objective: The aim of this study is to evaluate the diagnostic performance of PSAbased parameters in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and to determine the relation between serum PSA and histopathological grade in PCa. Methods: This retrospective study includes data of 320 patients with PCa (n: 155) and BPH patients (n: 165). Serum PSA levels and Gleason scores of pa...

The study of various countries rail transportation indicators is an appropriate criterion for evaluating the existing performance of Iranian railways. The experiences of other countries can be used to improve the efficiency of Iran’s rail transportation. At the beginning of the study, in order to compare the Iranian railway performance with railways of other countries, various efficiency indica...

Introduction: Brachytherapy, especially using manually after loaded Iridium-192 and Cobalt-60, can be applied as a sole treatment, as a treatment complementary to surgery, and as a local boost in combination with EBRT. The use of HDR brachytherapy catheters incorporated in removable dental molds allows repeated, highly reproducible, fractionated outpatient brachytherapy of supe...

This work describes the sequential hydrolysis of bambuterol enantiomers and their monocarbamate metabolites (MONO) catalyzed by human butyrylcholinesterase (BChE) as well as the enzyme inhibition resulting from this process. Particular emphasis is given to the contribution given by MONO to the enzyme inhibition because it was not fully characterized in previous works. Bambuterol and MONO enanti...

The current report assessed the effects of low-level proton irradiation in inbred adult male Fischer 344 and Lewis rats performing an analog of the human Psychomotor Vigilance Test (PVT), commonly utilized as an object risk assessment tool to quantify fatigue and sustained attention in laboratory, clinical, and operational settings. These strains were used to determine if genetic differences in...

this study was designed to determine the effects of dietary replacement of fish oil with canola oil ongrowth performance, feed efficiency of body and economic indices of experimental diets of juvenilecommon carp (cyprinus carpio). during the experiment 270 juvenile fish with an average initialweight of 16.24 ± 0.10g were randomly distributed in 18 well aerated cylindrical polyethylene tanks(15 ...