Résumé : La logique de similarité comparative des concepts CSL a été introduite en 2005 par Shremet, Tishkowsky, Wolter et Zakharyaschev pour représenter des informations qualitatives sur la similarité entre des concepts, du type “A est plus similaire à B qu’à C”. La sémantique utilise des espaces de distances afin de représenter le degré de similarité entre objets du domaine. Dans cet article,...

Selected area channeling patterns imaged on an SEM are digitized and displayed on the screen of a Macintosh computer, on which the user selects channeling bands that are measured to determine orientation. Grain boundary misorientations are found using the orientation information for pairs of grains adjacent at grain boundaries, and the boundaries are classified as low angle boundaries (LABs), c...

NOTCH3 gene amplification plays an important role in the progression ofmany ovarian and breast cancers, but the targets of NOTCH3 signaling are unclear. Here, we report the use of an integrated systems biology approach to identify direct target genes for NOTCH3. Transcriptome analysis showed that suppression of NOTCH signaling in ovarian and breast cancer cells led to downregulation of genes in...

NOTCH3 gene amplification plays an important role in the progression of many ovarian and breast cancers, but the targets of NOTCH3 signaling are unclear. Here, we report the use of an integrated systems biology approach to identify direct target genes for NOTCH3. Transcriptome analysis showed that suppression of NOTCH signaling in ovarian and breast cancer cells led to downregulation of genes i...

The Notch and transforming growth factor-beta (TGF-beta) signaling pathways play critical roles in the control of cell fate during metazoan development. However, mechanisms of cross-talk and signal integration between the two systems are unknown. Here, we demonstrate a functional synergism between Notch and TGF-beta signaling in the regulation of Hes-1, a direct target of the Notch pathway. Act...

Included in the New Zealand Government’s green paper “ A Future Tertiary Education Policy for New Zealand is the intention to put in place common quality standards, standard methods for reporting programs of study, and a national system to record all students registered in any paper at any tertiary institution. Through the National Qualifications Framework (NQF) the government asserts the right...

Somatic activating mutations in the Notch1 receptor result in the overexpression of activated Notch1, which can be tumorigenic. The goal of this study is to understand the molecular mechanisms underlying the phenotypic changes caused by the overexpression of ligand independent Notch 1 by using a tetracycline inducible promoter in an in vitro embryonic stem (ES) cells/OP9 stromal cells coculture...

In the developing central nervous system (CNS), Notch signaling preserves progenitor pools and inhibits neurogenesis and oligodendroglial differentiation. It has recently been postulated that Notch instructively drives astrocyte differentiation. Whether the role of Notch signaling in promoting astroglial differentiation is permissive or instructive has been debated. We report here that the astr...

INTRODUCTION Our aims were to analyze adhesion of periodontopathogens to self-ligating brackets (Clarity-SL [CSL], Clippy-C [CC] and Damon Q [DQ]) and to identify the relationships between bacterial adhesion and oral hygiene indexes. METHODS Central incisor brackets from the maxilla and mandible were collected from 60 patients at debonding after the plaque and gingival indexes were measured. ...

The galaxy image pair CSL-1 has been a leading candidate for a cosmic string lens. High quality imaging data from the Hubble Space Telescope presented here show that it is not a lens but a pair of galaxies. The galaxies show different orientations of their principal axes, not consistent with any lens model. We present a new direct test of the straight-string lens model, using a displaced differ...