The aim of this study is to provide new insights into the social innovation (SI) development process in context start-ups. A multiple case identifies issues and mechanisms for start-ups develop a need potentially scalable validate scale it up, while avoiding possible failure. Results show that key challenges faced by can be characterized according stage SI path. Firstly, start-ups' failure caus...

Soft tissue sarcomas (STS) are often described as asymptomatic, rapidly expanding masses, particularly in the extremities or trunk. Undifferentiated pleomorphic sarcoma (UPS), a high-grade variant of STS, ranks second most prevalent subtype United States. It predominantly affects males between their fifth and seventh decades. Its benign symptomatology, however, can lead to initial misdiagnosis ...

Undifferentiated pleomorphic sarcomas (UPSs) are aggressive mesenchymal malignancies with no definitive cell of origin or specific recurrent genetic hallmarks. These tumors are largely chemoresistant; thus, identification of potential therapeutic targets is necessary to improve patient outcome. Previous studies demonstrated that high expression of activated protein kinase B (AKT) in patients wi...