Gastrointestinal absorption and disposition of ketones is complex. Recent work describing the pharmacokinetics (PK) of d-β-hydroxybutyrate (BHB) following oral ingestion of a ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate) found multiple input sites, nonlinear disposition and feedback on endogenous production. In the current work, a human systems pharmacology model for gastrointesti...

Minerals and some biochemical parameters determined from blood serum analyses in left displacement abomasum (LDA) affected and healthy dairy cows to evaluate the effect of displacement abomasum on mineral status, energy metabolism and liver function. Samples were collected from 60 affected cows and 60 healthy control cows matched with cases, based on herd, parity, and stage of lactation. Concen...

Glycerol (G), polyglycerols (PGs), glycerol triacetate (GTA), and tributyrate (GTB) were studied as additives of poly(3-hydroxybutyrate) (PHB). The effect different concentrations (5–30%) these compounds on microstructure final properties PHB films evaluated. Microscopic studies revealed that samples with GTA GTB presented uniform microstructure, meanwhile those containing G PGs evidenced exuda...