Diabetes mellitus (DM) is an independent risk factor for heart disease and its underlying mechanisms are unclear. Increased expression of diabetic marker miR-29 family miRNAs (miR-29a, b and c) that suppress the pro-survival protein Myeloid Cell Leukemia 1(MCL-1) is reported in pancreatic β-cells in Type 1 DM. Whether an up-regulation of miR-29 family miRNAs and suppression of MCL-1 (dysregulat...

portant factor in the calculations. There is agreement between the present mean life results 2. P. C.Rogers, FRANTIC, M.I.T. Lab. for Nucl. Sci., Report ‘76 (1962). and the recent beam-foil measurements of Heroux [ 31 and Bromander [ 51 and with the elec tron impact phase-shift method results of Lawrence [4]. 3. L.Heroux, Phys. Rev. 180 (1969) 1. 4. G.M.Laarence and B.D.Sabage; Phys. Rev. 141 (...

MicroRNAs (miRNAs) are small non-coding RNAs that regulate target gene expression by binding to the 3′untranslated region (3′UTR) of the target mRNA. MiRNAs regulate a large variety of genes, including those involved in liver biology and disease. Here, we report for the first time that miR-29a post-transcriptionally regulates stearoyl-CoA desaturase (SCD) by binding to its 3′UTR in genetically ...

subgroup analyses are hypothesis generating at best. An ongoing randomized controlled trial will hopefully shed further light on the potential benefit of LMWH to prevent recurrent pregnancy loss in thrombophilic women (www. trialregister.nl #NTR 3361). The bottom line is that we need further research to explore whether LMWH can improve live birth rates in women with thrombophilia. However, unti...