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BACKGROUND Computer-based learning (CBL) has been widely used in medical education, and reports regarding its usage and effectiveness have ranged broadly. Most work has been done on the effectiveness of CBL approaches versus traditional methods, and little has been done on the comparative effects of CBL versus CBL methodologies. These findings urged other authors to recommend such studies in ho...
CAECILIA-DESIREE HEIN, Cicero als philosophischer Schriftsteller. Kommentar zu ausgewählten Briefen aus den Jahren 45–44, (Wissenschaftliche Kommentare Griechischen und Lateinische), Heidelberg: Universitätsverlag Winter, 2019, 251 pp., 58,00 €, ISBN 9
High purity human Lu-thrombin was labeled with “‘Iby lactoperoxidase-catalyzed iodination and was conjugated with the photoreactive reagent N-(4-azido-2nitrophenyl)-2-diaminoethane (NAPEDE) by carbodiimide coupling. Cultured mouse embryo fibroblasts, which respond mitogenically to cu-thrombin, bound the conjugated and unconjugated enzyme similarly, indicating that the NAPEDE group did not signi...
Differentiation therapy is used in cancer treatment. Epidemiologic studies showed that higher vitamin D levels are associated with reduced cancer risks. However, the therapeutic doses needed for differentiation are accompanied by hypercalcemia and intolerable pathological sequelae. In the present work we evaluated if RRD-251, a small-molecule, can enhance vitamin D3-induced differentiation of l...
The tumour suppressor gene product Mig-6 acts as an inhibitor of epidermal growth factor (EGF) signalling. However, its posttranslational modifications and regulatory mechanisms have not been elucidated. Here, we investigated the phosphorylation of human Mig-6 and found that Chk1 phosphorylated Mig-6 in vivo as well as in vitro. Moreover, EGF stimulation promoted phosphorylation of Mig-6 withou...
We present an O(n)-time randomized approximation algorithm for the maximum traveling salesman problem whose expected approximation ratio is asymptotically 251 331 , where n is the number of vertices in the input (undirected) graph. This improves the previous best.
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