The objective of this study is to evaluate the activity of a novel peptide, i.e., bifunctional peptide inhibitor (BPI), which targets the immunological synapse and inhibits autoimmune responses in an antigen-specific manner. Proteolipid protein (PLP)-BPI was designed by conjugating two peptides, an encephalitogenic epitope of proteolipid protein (PLP(139-151)) and an intercellular adhesion mole...

Plant growth promoting endophytic bacteria (PGPB) isolated from Brassica napus were inoculated in two cultivars of Helianthus tuberosus (VR and D19) growing on sand supplemented with 0.1 mM Cd or 1 mM Zn. Plant growth, concentrations of metals and thiobarbituric acid (TBA) reactive compounds were determined. Colonization of roots of H. tuberosus D19 by Pseudomonas sp. 262 was evaluated using co...

Book review on Jaroslav Pinkas, Jak vzpomínáme na normalizaci. Obrazy normalizační minulosti ve filmu. Karolinum, Ústav pro studium totalitních režimů, Praha 2020, 236 s., ISBN 978-80-246-4831-6.

s / Porto Biomed. J. 2017;2(5):176–246 221 of PT2020, to INNOVMAR (NORTE-01-0145-FEDER-000035, NOVELMAR), supported by NORTE 2020, under PORTUGAL 2020, through ERDF. To Dr. S Cravo for technical assistance.

Histological evidence of glomerulonephritis is reported in 95 (38.6%) of a series of 246 necropsies with concomitant rheumatic carditis. The details of these findings are given and their significance is discussed.

A core-shell photoanode, composed of a monoclinic WO3 nanorods core encapsulated with a rutile TiO2 nanoparticles shell, reveals ~246% enhancement in power conversion efficiency due to improved current density and open circuit voltage values and longer-lived charge carriers.

Orthopoxviruses, such as variola and monkeypox viruses, can cause severe disease in humans when delivered by the aerosol route, and thus represent significant threats to both military and civilian populations. Currently, there are no antiviral therapies approved by the U.S. Food and Drug Administration (FDA) to treat smallpox or monkeypox infection. In this study, we showed that administration ...

Background: The occurrence of adverse cardiac events always disturbs the successful recovery, personal and economic life of patients undergoing major abdominal surgery. This study aimed to gain further insight into potential predicators for adverse cardiac events after major abdominal surgery. Methods: 246 patients who scheduled to undergo selective major abdominal surgery were eligible to ente...

CD40 activates nuclear factor kappa B (NF kappa B) and the mitogen-activated protein kinase (MAPK) subfamily, including extracellular signal-regulated kinase (ERK). The CD40 cytoplasmic tail interacts with tumor necrosis factor receptor-associated factor (TRAF)2, TRAF3, TRAF5, and TRAF6. These TRAF proteins, with the exception of TRAF3, are required for NF kappa B activation. Here we report tha...

Analytical interferences have been described due to the presence of various exogenous UV-absorbing substances in serum. Iodine-based X-ray contrast agents and various antibiotics have been reported to interfere with interpretation of serum protein pherograms, resulting in false diagnosis of paraproteinemia. In the present study, we have explored the possibility of measuring UV absorbance at two...