3 Weinbach, E. C., J. Biol. Chem., 221, 609 (1956). 4Lehninger, A. L., J. Biol. Chem., 234, 2187 (1959). 6 Lehninger, A. L., B. L. Ray, and M. Schneider, J. Biophys. Biochem. Cytol., 5, 97 (1959). 6 The analyses of pentachlorophenol were based on its absorption maximum at 320 m/t in alkali. 7 Lehninger, A. L., and L. E. Remmert, J. Biol. Chem., 234, 2459 (1959). 8 Weinbach, E. C., J. Biol. Chem...

Synaptotagmin 1 binds Ca2+ and membranes via its C2A-domain and plays an essential role in excitation-secretion coupling. In this study, we sought to identify Ca2+- and membrane-induced local conformational changes in the C2A-domain of synaptotagmin and to delineate the C2A-lipid binding interface. To address these questions native phenylalanine residues were replaced, at each face of the domai...

OBJECTIVE To study the efficiency of research implementation in a large radiotherapy institute, in either an internal review board-approved clinical trial or clinical routine. METHODS Scientific publications of the institute were listed. We asked clinicians from tumour expert groups whether the study had been implemented yet in a clinical trial or in clinical practice and which facilitators o...

Yeast chorismate mutase (EC 5.4.99.5) shows homotropic activation by the substrate, allosteric activation by tryptophan, and allosteric inhibition by tyrosine. In this study mutants of chorismate mutase have been found that remain sensitive to one allosteric effector (tryptophan) but insensitive to the other (tyrosine). These mutations are located in the catalytic domain: loop 220s (212-226) an...

OBJECTIVES To determine the extent to which clinical and radiographic features of bisphosphonate-associated osteonecrosis of the jaw (BONJ) are correlated. DESIGN Retrospective case review. METHODS The records of 39 patients diagnosed with BONJ and examined by panoramic radiography were retrospectively evaluated. The arches were divided into sextants (n = 234) and evaluated for the followin...

The accuracy of the duplex scan with spectral analysis (DS/SA) in predicting the presence of arteriographic carotid stenosis was compared to that of oculoplethysmography/carotid phonoangiography (OPG/CPA) in 234 vessels from 117 patients who had had both non-invasive studies in addition to independently interpreted arteriograms. The DS/SA with 212/234 (91%) overall correct responses was superio...

Introduction. Adherence to antiretroviral therapy (ART) in low-income countries is mainly assessed by self-reported adherence (S-RA) without drug level determination. Nonadherence is an important factor in the emergence of resistance to ART, presenting a need for drug level determination. Objective. We set out to establish the relationship between plasma stavudine levels and S-RA and validate S...

Ce court article formule quelques hypothèses susceptibles d’éclairer la centralité du secret dans l’histoire des remèdes. Il évoque pour cela plantes médicinales Nouveau Monde. Entre 1492 et fin xviiie siècle, en effet, transmission de ces remèdes a souvent été perturbée par pratique secret, qui pouvait poursuivre diff&#233...

The authors establish certain results concerning the quasi-Hadamard product of analytic and p-valent functions with negative coefficients analogous to the results due to Vinod Kumar (J. Math. Anal. Appl. 113(1986), 230-234 and 126(1987), 70-77).