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The main objective of the present study was to develop colon targeted drug delivery systems for Nitrofurantoin using guar gum as a carrier. Matrix tablets containing various proportions of guar gum were prepared by wet granulation technique using starch paste as a binder. The in-vitro drug release study was undertaken at 37±0.5°C in 0.1N Hcl for 2 hr; followed by pH 7.4 phosphate buffer (3hr) f...
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Superresolution by data inversion is the extrapolation of measured Fourier data to regions outside the measurement bandwidth using postprocessing techniques. Here we characterize superresolution by data inversion for objects with finite support using the twin concepts of primary and secondary superresolution, where primary superresolution is the essentially unbiased portion of the superresolved...
Pollard and J. M. Walker, eds. Clifton, N.J.: Humana Press. Reichmann, L., M. Clark, H. Waldmann, and G. Winter. 1988. Reshaping human antibodies for therapy. Nature 332:323-327. Reiter, Y., U. Brinkmann, K. O. Webber, SH. Jung, B. Lee, and I. Pastan. 1994. Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: Improved biochemical characteristics of recombinan...
Background: Differences in efficacy outcomes favouring males vs females with rheumatoid arthritis (RA) have been reported conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs) and tumour necrosis factor inhibitors; results Janus kinase inhibitors are less clear. Objectives: To assess the impact of sex on efficacy, safety persistence tofacitinib RA clinical trials. Methods: ...
Introduction In vivo proton magnetic resonance spectroscopy (H-MRS) has been used to measure metabolic changes in the brain of epilepsy patients. Significantly reduced NAA/total creatine (tCr) ratios have been observed in the hippocampus and/or thalamus of patients with temporal lobe epilepsy (TLE), indicative of neuronal dysfunction/loss in these regions [1]. Pentylenetetrazol (PTZ) is a GABAA...
We present new methods for optimizing the spatial bandwidth capacity in off-axis holography using spatial multiplexing. We use optimal spatial multiplexing of off-axis holograms to fill the entire spatial frequency domain, including the space previously occupied by the intensity of the sample. Our approach enables spatial digital compression of eight offaxis holograms into a single real-valued ...
Aim of review: Ganglioside GM1is a major ganglioside component, which has been shown to potentiate the action of neurotrophins and display a wide variety of CNS functions amongst many neurologic conditions including cerebral ischemic injury. This mini-review aims to summarize the latest knowledge of the possible neuro-reparative properties of GM1 in ischemic stroke in the past ten years. Method...
w x50 Belardinelli L, Linden J, Berne R. The cardiac effects of adenosine. Prog Cardiovasc Dis 1989;32:73–97.w x51 Olafson B, Forman MB, Puett DW. Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon. Circulation 1987;76:1135–1145.w x52 Kirsch GE, Codina J, Birnbaumer L, Brown AM....
The ,,t (GSTMJ) and 0 (GSTTJ) members of the glutathione S-transferase multigene family are candidate cancer susceptibility genes because of their ability to regulate the conjugation of carcinogenic compounds to excretable hydrophilic metabolites. Deletion variants that are associated with a lack of enzyme function exist at both of these loci. Individuals who are carriers of homozygous deletion...
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