Purpose: Expression of HER2 has profound implications on treatment strategies in various types of cancer. We investigated the specificity of radiolabeled HER2-targeting ZHER2:2891 Affibody, [F]GE-226, for positron emission tomography (PET) imaging. Experimental design: Intrinsic cellular [F]GE-226 uptake and tumor-specific tracer binding were assessed in cells and xenografts with and without dr...

PURPOSE Expression of HER2 has profound implications on treatment strategies in various types of cancer. We investigated the specificity of radiolabeled HER2-targeting ZHER2:2891 Affibody, [(18)F]GE-226, for positron emission tomography (PET) imaging. EXPERIMENTAL DESIGN Intrinsic cellular [(18)F]GE-226 uptake and tumor-specific tracer binding were assessed in cells and xenografts with and wi...

The photodissociation dynamics of state selected OD radicals has been examined at 243 and 226 nm using velocity map imaging to probe the angle–speed distributions of the D(S) and O(P2) products. Both experiment and complementary first principle calculations demonstrate that photodissociation occurs by promotion of OD from high vibrational levels of the ground X P state to the repulsive 1 S stat...

So far we have considered the Bayesian detection problem of minimizing E(c(X, g(Y))) when both pX and fY|X are known. Recall that, when X ∈ {0, 1} the optimal decision has the form g(Y) = h(Λ(Y)) where Λ(y) = fY|X [y|1]/fY|X [y|0] is the likelihood ratio. In particular, if Λ(y) = f(k(y)), then k(Y) is a sufficient statistic for detecting X given Y. In this section we explore the detection probl...

The photochemistry and dynamics of small C6H6–O2 clusters were studied in a supersonic expansion using 226 nm laser excitation and multiphoton ionization probes. We were able to detect a strong signal due to O(P2) when mixed clusters were present in the expansion but no O atom fragments could be observed in the absence of benzene in the expansion mixture. Photofragmentation of O2 in the unique ...

BACKGROUND The objective of this study was to estimate the frequency of Y chromosome microdeletions in the Slovenian population of infertile men and to analyse the consequences of mutation in respect to clinical severity and prognosis. METHODS In a controlled clinical study at the university-based medical genetics service and infertility clinic, 226 infertile men undergoing ICSI were tested. ...

High-Z nano materials have been previously shown to increase the amount of dose deposition within the tumour due to an increase in secondary electrons. This study evaluates the effects of high-Z nano materials in combination with protons, and the impact of proton energy, nanoparticle material and concentration. These effects were studied in silico through Monte Carlo simulation and experimental...

the existence of ra 226 is proved and measured by radiom emanation-method in waters and food products of north , north west and north – east of iran. a total of 126 water, 249 food and 22 air samples have been examined. the concertration of ra 226 in waters found to be 0.01 to 1.104 pci/1 and in food products from 0.01 to pci/gr. ash.the amount found in due ranges from 0.003 to 0.227 pci/m 3.it...

Radium ((226)Ra) contamination derived from military, industrial, and pharmaceutical products can be found at a number of historical sites across the world posing a risk to human health. The analysis of spectral data derived using gamma-ray spectrometry can offer a powerful tool to rapidly estimate and map the activity, depth, and lateral distribution of (226)Ra contamination covering an extens...

China has been undergoing a remarkably rapid urbanization process in the last several decades. Urbanization is a complicated phenomenon involving imbalanced transformation processes, such as population migrations, economic advancements and human activity dynamics. It is important to evaluate the imbalances between transformation processes to support policy making in the realms of environmental ...