The objective of this study was to compare the demographic and vascular characteristics and APOE genotypes of a dysexecutive subgroup of Alzheimer disease (AD) with an amnestic subgroup of AD early in the disease course. A total of 2224 participants from the National Alzheimer's Coordinating Center database who carried a diagnosis of mild cognitive impairment (n=1188) or mild AD (clinical demen...

94 Ann Dermatol Received November 6, 2013, Revised January 5, 2014, Accepted for publication February 1, 2014 Corresponding author: Chul Woo Kim, Department of Dermatology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 150 Seongan-ro, Gangdong-gu, Seoul 134-701, Korea. Tel: 82-2-2224-2285, Fax: 82-2-474-7918, E-mail: [email protected] This is an Open Access article di...

The current mainstream in economic research is intensively supplemented by new modelling paradigms that have been established only recently. Application of agent-based modelling in the realm of economic systems labelled as Agent-based Computational Economics (ACE) represents one rapidly evolving approaches. On the other hand, there is a lack of research focused on timebanks (TBs) as an economic...

Allelic variation at 4 loci in the human olfactory receptor gene OR7D4 is associated with perceptual variation in the sex steroid-derived odorants, androstenone, and androstadienone. Androstadienone has been linked with chemosensory identification whereas androstenone makes pork from uncastrated pigs distasteful ("boar taint"). In a sample of 2224 individuals from 43 populations, we identified ...

MicroRNAs (miRNAs) are often deregulated in cancer and are thought to play an important role in cancer development. Large amount of differentially expressed miRNAs have been identified in various cancers by using high-throughput methods. It is therefore quite important to make a comprehensive collection of these miRNAs and to decipher their roles in oncogenesis and tumor progression. In 2010, w...

The mechanism by which anaesthetics work is much discussed. The most prevalent view is that anaesthetics bind to ligand gated ion channels thereby restricting their function. Another view is that anaesthetics interact directly with the cell membrane, changing properties of the membrane leading to a conformational change in the membrane proteins which causes anaesthesia. In this thesis we will i...

BACKGROUND The study was planned to review the case series of pregnant women requiring intensive care due to severe acute maternal morbidity in the public sector university hospital, in order to identify failures and priorities in maternal health care provision in Pakistan. METHODS A retrospective case series study was performed of critically ill obstetrics patients admitted to general intens...

High N depositions of past decades brought changes to European forests including impacts on forest soil nutrition status. However, the ecosystem responses declining atmospheric inputs or moderate attracted only less attention so far. Our study investigated macronutrient (N, S, Ca2+, Mg2+, K+) pools and fluxes at conversion sites over 80 years old in Central Germany with beech (so-called “Green ...

Liver cirrhosis is recognized as being the consequence of immune-mediated hepatocyte damage and repair processes. However, the regulation of these immune responses underlying liver cirrhosis has not been elucidated. In this study, we used GEO datasets and bioinformatics methods to established coding and non-coding gene regulatory networks including transcription factor-/lncRNA-microRNA-mRNA, an...

The intraerythrocytic malaria parasite derives much of its requirement for amino acids from the digestion of the hemoglobin of its host cell. However, one amino acid, isoleucine, is absent from adult human hemoglobin and must therefore be obtained from the extracellular medium. In this study we have characterized the mechanisms involved in the uptake of isoleucine by the intraerythrocytic paras...