The incidence of oral squamous cell carcinoma (OSCC) is rising rapidly in developed countries, posing a growing challenge due to the poor management of this type of malignancy at present. In this study, we profiled tumor suppressive microRNAs (miRNAs) that are silenced by DNA hypermethylation in OSCC using a function-based screening approach. This approach employed a cell proliferation assay fo...

Mammalian blastocyst formation is characterized by two lineage segregations resulting in the formation of the trophectoderm, the hypoblast, and the epiblast cell lineages. Cell fate determination during these early lineage segregations is associated with changes in the expression of specific transcription factors. In addition to the transcription factor-based control, it has become clear that a...

PURPOSE To evaluate the appropriateness of prophylactic inguinal nodal irradiation (PINI), we analyzed patterns of failure in anal cancer patients who were inguinal node-negative at presentation and did not receive PINI. MATERIALS AND METHODS We retrospectively reviewed the records of 33 anal cancer patients treated by definitive concurrent chemoradiation therapy (CCRT) between 1994 and 2013....

Glycine receptors (GlyRs) are chloride channels that mediate fast inhibitory neurotransmission and are members of the pentameric ligand-gated ion channel (pLGIC) family. The interface between the ligand binding domain and the transmembrane domain of pLGICs has been proposed to be crucial for channel gating and is lined by a number of charged and aromatic side chains that are highly conserved am...

1. Bovine inositol monophosphatase reacts with thiol reagents such as 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB), N-ethylmaleimide (NEM) and iodoacetic acid (IAA). 2. Modification by NEM results in nearly total loss of enzyme activity, whereas modification by IAA causes a slight increase in activity. 3. The loss of activity caused by NEM can be prevented by the inclusion of Ins1P, or better In...

This work presents an example of a cooperative system of truncated linear recursions in which the interaction between species causes one of the species to have an anomalous spreading speed. By this we mean that this species spreads at a speed which is strictly greater than its spreading speed in isolation from the other species and the speeds at which all the other species actually spread. An e...

Yûnus Emre, hümanizm felsefesinin tartışılmaz önderlerinden biri olarak Türk dili, tarihi ve edebiyatında önemli bir yere sahiptir. Şiirlerinin hem içerik de sanatsal değeri çok sevilmesine yol açmıştır. Bu nedenle eserlerinin pek nüshası bulunmaktadır.
 çalışmada Yunus Emre Dîvânı’nda geçen dört büyük melekten olan İsrâfil’in Kıyamet Günü’nde üfleyeceği boru Sûr ile birlikte kullanılan ya...

Fundacio Infermeria i Societat del Colegio de Enfermeras y Enfermeros Barcelona (PR-218/2017).