17 LFF571 is a novel semi-synthetic thiopeptide antibacterial that is undergoing investigation for 18 safety and efficacy in patients with moderate C. difficile infections. LFF571 inhibits bacterial 19 protein synthesis by interacting with elongation factor Tu (EF-Tu) and interrupting complex 20 formation between EF-Tu and aminoacyl-tRNA. Given this mechanism of action, we 21 hypothesized that ...

Background: The frequent need for blood transfusion in children with SCA creates the impression that IDA is rare in this class of children. Objectives: The objective of the study is to determine the prevalence of IDA in a population of under-five children with SCA in Lagos, Nigeria. Methodology: Serum iron, total iron binding capacity, transferrin saturation and serum ferritin were assayed in 9...

Neural network modelling has been applied to search for novel high strength steel weld metal compositions, potentially offering improved tolerance to variations in the weld thermal cycle. An experimental 7 wt% Ni manual metal arc electrode, formulated on these predictions, was used to produce all-weld metals and welds in high strength steel. Mechanical properties were correlated to weld metal m...

A double antibody sandwich enzyme immunoassay (EIA) for chlamydial antigen detection was developed using a monoclonal antibody against lipopolysaccharide (LPS) of Chlamydia trachomatis as a coating antibody. Polyclonal rabbit antiserum against partially purified antigen from elementary body (EB) antibody and horse-radish peroxidase conjugated goat anti-rabbit antibody were used as the primary a...

The immunostimulatory effects of intraperitoneally injected Chevimmun, a fixed combination herbal product, was investigated in the rainbow trout. Administration of a 75% Chevimmun preparation resulted in significantly enhanced leucocyte migration (p<0.05), phagocytosis (p<0.001) and respiratory burst activity (p<0.001) in the peritoneal cavity. Antiprotease activity was also significantly eleva...

Flexural fatigue tests are typically run under displacement or in a straincontrolled mode. In these tests, either the oscillatory displacement amplitude or strain amplitude applied to the bottom of the specimen is kept constant. The evolution of loading required to cause fatigue is then measured. Load amplitude decreases with the number of cycles, and the specimen is considered to have failed w...

The influence of ethanol on the miscibility transition of model bilayers containing cholesterol was investigated with fluorescence microscopy. A biphasic effect of the miscibility transition temperature and the presence of non-spherical vesicles were observed. Ethanol still has the disordering effect and reduces the transition temperature by ~2 °C at ~0.54M; nevertheless, this effect gets atten...

Entomopathogenic fungus Beauveria bassiana is widely used as the microbial pesticide (biological control agent) in agriculture and many studies are reported that Beauveria also possesses active secondary metabolites which are medicinally significant. The present study is to assay the antiviral, anticancer and anti-inflammatory activity of metabolites from B. bassiana local isolate that is extra...

We demonstrate direct-modulation of a discrete mode laser using Discrete Multi-Tone modulation for transmission distances up to 100 km in the 1550 nm band. A large operational temperature range (0-65oC) is also demonstrated. Introduction High-capacity and low-cost transmission over distances of up to 80 km is of interest for interdata centre communications and short-reach metro networks1. Direc...

This case is reported with the intention of highlighting the presentation of primary intestinal amoebic disease in Heckel discus Symphysodon discus. The morphology of the parasites and the pathological changes seen using light microscopy were essential. In fresh samples of intestinal content we discovered numerous amoeba-like cells. The trophozoite measures 18.6 x 10.2 mm while the cyst is 11-2...