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Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic andwild cats. The Pallas’ cat is the only species fromAsia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28wildMongolian Pallas’ cats sampled from 2000 to 2008. Phylogenetic analysis of prov...

Genes encoding thaumatin-like protein (TLPs) are frequently found in fungal genomes. However, information on TLP genes in Polyporus umbellatus is still limited. In this study, three TLP genes were cloned from P. umbellatus. The full-length coding sequence of PuTLP1, PuTLP2 and PuTLP3 were 768, 759 and 561 bp long, respectively, encoding for 256, 253 and 187 amino acids. Phylogenetic trees showe...

Standardized, high-throughput RNA detection with microarray chips allows for the construction of genome-wide databases for tissue specimens suitable for in silico electronic Northern blot (eNorthern) analysis of marker genes. We used the BioExpressTM database, which contains transcriptional profiles of normal and cancer samples, to examine two putative markers of cancer stroma: fibroblast activ...

Prostate-specific membrane antigen (PSMA), whose expression is upregulated in poorly differentiated, metastatic, and hormone refractory prostate cancer, could be targeted by gene-based vaccines. The aim of this study was to characterize the humoral immune response against PSMA in prostate carcinoma patients who have been vaccinated against PSMA with gene-based vaccines. Sera from prostate cance...

The withdrawal of immunosuppression is effective in treating lymphoproliferative diseases arising in organ transplant recipients. We report a case of a durable complete response in a melanoma patient following discontinuation of immunosuppression. A male with aplastic anemia since 1997 was treated with cyclosporine until 2001 when immunosuppression was changed to sirolimus plus tacrolimus to li...

We conducted an open label dose-escalation phase I trial of chimeric anti-GD3 mAb KM871 in patients with metastatic melanoma. Patients were entered into one of five dose levels (1, 5, 10, 20, and 40 mg/m2) and received three infusions of KM871 at 2-wk intervals. A metastatic melanoma site was biopsied at day 7-10. Pharmacokinetics, immune function, and mechanism of action of KM871 were analysed...

seven hundred and sixty-eight blood samples of pregnant cattle from four holstein dairy herds that are farmed in the vicinity of tehran were used to evaluate the seroprevalence of neospora caninum infection by enzyme-linked immunosorbent assay (elisa). two hundred and ninety-eight of the 768 blood samples (38.8%) were positive for this infection. the prevalence of infection in the herds varied ...