During infection and inflammation there is a cascade of reactions that occurs in the host collectively known as the acute-phase response (APR).1 Besides alterations in acute-phase reactants (plasma proteins), the APR is also associated with changes in lipoproteins.2 Increasing evidence suggests that high density lipoproteins (HDL) are a critical part of the acute phase response (APR) of the inn...

Introduction: Diabetes mellitus is associated with derangements in the serum levels of several biochemical parameters. Fibrinogen is a strong cardiovascular risk factor in the general population, and increased fibrinogen plasma concentrations have been reported in type 2 diabetic patients. Purpose: To assess fibrinogen, lipids and lipoprotein composition and the relationship between fibrinogen ...

OBJECTIVE Apolipoprotein C-I (apoC-I) influences lipoprotein metabolism, but little is known about its cellular effects in aortic smooth muscle cells (ASMC). METHODS AND RESULTS In cultured human ASMC, apoC-I and immunoaffinity purified apoC-I-enriched high-density lipoproteins (HDL) markedly induced apoptosis (5- to 25-fold), compared with control cells, apoC-I-poor HDL, and apolipoprotein C...

AIMS High-density lipoprotein (HDL) has been reported to have cardioprotective properties independent from its cholesterol transport activity. The influence of native HDL and reconstituted HDL (rHDL) on Stat3, the transcription factor playing an important role in myocardium adaptation to stress, was analysed in neonatal rat ventricular cardiomyocytes. We have investigated modulating the composi...

High-density lipoproteins (HDL) possess key atheroprotective biological properties, including cellular cholesterol efflux capacity, and anti-oxidative and anti-inflammatory activities. Plasma HDL particles are highly heterogeneous in physicochemical properties, metabolism, and biological activity. Within the circulating HDL particle population, small, dense HDL particles display elevated cellul...

Turks have strikingly low levels of high density lipoprotein cholesterol (HDL-C) (10-15 mg/dL lower than those of Americans or Western Europeans) associated with elevated hepatic lipase mass and activity. Here we report that Turks have low levels of high density lipoprotein subclass 2 (HDL(2)), apoA-I-containing lipoproteins (LpA-I), and pre-beta-1 HDL and increased levels of HDL(3) and LpA-I/A...

The lipid mediator sphingosine 1-phosphate (S1P) confers survival benefits in cardiomyocytes and isolated hearts subjected to oxidative stress. High-density lipoprotein (HDL) is a major carrier of S1P in the serum, but whether HDL-associated S1P directly mediates survival in a preparation composed exclusively of cardiomyocytes has not been demonstrated. Accordingly, we tested the hypothesis tha...

Prospective population studies have shown that a raised concentration of high density lipoprotein (HDL) cholesterol is associated with a reduced incidence of coronary events and atherosclerotic progression. 2 According to one paradigm any raised concentration of HDL cholesterol is beneficial to health. This is, however, challenged by two unexplained observations. Firstly, in populations with he...