The ongoing COVID-19 pandemic has clearly established how vital rapid, widely accessible diagnostic tests are in controlling infectious diseases and difficult slow it is to scale existing technologies. Here, we demonstrate the use of rapid affinity pair identification via directed selection (RAPIDS) method discover multiple pairs for SARS-CoV-2 nucleocapsid protein (N-protein), a biomarker COVI...

Abstract Objectives Novel point-of-care antigen assays present a promising opportunity for rapid screening of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The purpose this study was the clinical assessment new Roche SARS-CoV-2 Rapid Antigen Test. Methods performance Test evaluated vs. reverse transcription polymerase chain reaction (RT-PCR) laboratory-based assay (Se...

Adoptive T-cell therapy (ACT) is a promising therapeutic approach based on the concept of potent mediated immunity against tumor. The outcome antigen-specific T-cells responses relies interaction between and antigen-presenting cells, which provides signals for generating different phenotypes with roles in tumor removal. However, such often not optimal vivo results low efficacy. To reach full po...

After immunization of mice with the human hepatocellular carcinoma (HCC) cell line PLC/PRF/5, we produced monoclonal antibody KM-2, which allowed us to characterize a new HCC-associated antigen (KM-2 antigen) and to develop a sandwich-type radioimmunoassay. The KM-2 antigen was strongly expressed on the cell surface of HCC cell lines. Immunofluorescence staining of frozen sections of different ...